Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype.
Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype.
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DOI：
10.1084/jem.20052237
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发表时间：
2006-04-17
期刊：
影响因子：
--
通讯作者：
Harty JT
中科院分区：
文献类型：
--
作者：
Jabbari A;Harty JT
记忆性CD8 T细胞的形成是疫苗接种的一个重要目标。然而，尽管在人类中广泛使用增强免疫可产生二级和三级CD8 T细胞记忆，但实验数据仅限于原发性CD8 T细胞记忆。在这里，我们表明，与初级记忆CD8 T细胞相比，二级记忆CD8 T细胞表现出明显延迟的向中央记忆表型的转化，这是由CD62L表达和白细胞介素(IL)-2产生决定的。这种向中央记忆表型的延迟转化与降低基础增殖和对IL-15的反应性相关，尽管在体外与高浓度IL-15共培养能够诱导增殖和CD62L上调。在功能上，二级记忆CD8 T细胞在体内对每个细胞具有更强的保护作用，这可以通过持续的分解能力来解释。此外，继发性记忆CD8 T细胞比原发性记忆CD8 T细胞更允许淋巴结中的新T细胞启动，这可能表明记忆T细胞的替代机制。因此，原发性和继发性记忆性CD8 T细胞在功能上是不同的，与抗原接触的次数会影响记忆性CD8 T细胞的功能。
The formation of memory CD8 T cells is an important goal of vaccination. However, although widespread use of booster immunizations in humans generates secondary and tertiary CD8 T cell memory, experimental data are limited to primary CD8 T cell memory. Here, we show that, compared with primary memory CD8 T cells, secondary memory CD8 T cells exhibit substantially delayed conversion to a central–memory phenotype, as determined by CD62L expression and interleukin (IL)-2 production. This delayed conversion to a central–memory phenotype correlates with reduced basal proliferation and responsiveness to IL-15, although in vitro coculture with a high concentration of IL-15 is capable of inducing proliferation and CD62L upregulation. Functionally, secondary memory CD8 T cells are more protective in vivo on a per cell basis, and this may be explained by sustained lytic ability. Additionally, secondary memory CD8 T cells are more permissive than primary memory CD8 T cells for new T cell priming in lymph nodes, possibly suggesting a mechanism of replacement for memory T cells. Thus, primary and secondary memory CD8 T cells are functionally distinct, and the number of encounters with antigen influences memory CD8 T cell function.
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影响因子：
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