One-Year Follow-Up Diagnostic Stability of Autism Spectrum Disorder Diagnosis in a Clinical Sample of Children and Toddlers.
One-Year Follow-Up Diagnostic Stability of Autism Spectrum Disorder Diagnosis in a Clinical Sample of Children and Toddlers.
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DOI：
10.3390/brainsci11010037
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发表时间：
2021-01-01
期刊：
影响因子：
3.3
通讯作者：
Gagliano A
中科院分区：
文献类型：
--
作者：
Benedetto L;Cucinotta F;Maggio R;Germanò E;De Raco R;Alquino A;Impallomeni C;Siracusano R;Vetri L;Roccella M;Ingrassia M;Gagliano A
一些研究表明，在18至24个月的儿童中，自闭症谱系障碍的诊断可以被认为是可靠和稳定的。然而，ASD早期诊断的稳定性还没有得到充分的证明。这项观察性研究在147名18至48个月大的儿童的临床样本中检验了自闭症谱系障碍诊断的一年诊断稳定性。使用ADOS-2评分将儿童按症状严重程度分为三个级别：自闭症(AD；比较分数5-7)、自闭症谱系障碍(ASD；比较分数3-4)和亚阈值症状(STS；比较分数1-2)。结果：总体而言，被诊断患有自闭症谱系障碍的18至48个月的儿童和蹒跚学步的儿童中，最大部分在一年的随访评估中继续表现出自闭症症状。然而，在ADOS严重程度评分较高的儿童中，有相当比例的儿童表现出症状严重程度的降低，因此在一年后转向较轻的严重级别。相反，STS组的受试者数量有意义地增加。因此，在一年的随访中，有统计学意义的(χ2(2)=181.46，p<；0.0001)在基线水平上接受了自闭症或自闭症谱系障碍分类诊断的受试者的百分比(25.2%)不再符合分类诊断标准。此外，不再符合自闭症谱系障碍标准的儿童在一个或多个神经发育领域继续表现出延迟，这可能与出现其他神经发育/神经精神障碍有关。总体而言，这项研究的综合结果说明ASD早期诊断的敏感性很高，但稳定性中等。
Some studies show that the diagnosis of Autism Spectrum Disorder could be considered reliable and stable in children aged 18 to 24 months. Nevertheless, the diagnostic stability of early ASD diagnosis has not yet been fully demonstrated. This observational study examines the one-year diagnostic stability of autism spectrum disorder diagnosis in a clinical sample of 147 children diagnosed between 18 and 48 months of age. The ADOS-2 scores were used in order to stratify children in three levels of symptom severity: Autism (AD; comparison score 5–7), Autism Spectrum Disorder (ASD; comparison score 3–4), and Sub-Threshold Symptoms; (STS; comparison score 1–2). Results: Overall, the largest part of children and toddlers diagnosed with autism spectrum disorder between 18 and 48 months continued to show autistic symptoms at one-year follow-up evaluation. Nevertheless, a significant percentage of children with higher ADOS severity scores exhibited a reduction of symptom severity and, therefore, moved towards a milder severity class one year later. Conversely, the number of subjects of the STS group meaningfully increased. Therefore, at one-year follow-up a statistically significant (χ2(2) = 181.46, p < 0.0001) percentage of subjects (25.2% of the total) who had received a categorical diagnosis of Autistic Disorder or Autism Spectrum Disorder in baseline no longer met the criteria for a categorical diagnosis. Furthermore, children who no longer met the criteria for autism spectrum disorder continue to show delays in one or more neurodevelopmental areas, possibly related to the emergence of other neurodevelopmental/neuropsychiatric disorders. Overall, the comprehensive results of the study account for a high sensibility but a moderate stability of ASD early diagnosis.
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影响因子：
3.1
作者：
Kantzer, Anne-Katrin;Fernell, Elisabeth;Miniscalco, Carmela
通讯作者：
Miniscalco, Carmela
DOI：
10.15585/mmwr.ss6706a1
发表时间：
2018-04-27
期刊：
Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002)
影响因子：
--
作者：
Baio J;Wiggins L;Christensen DL;Maenner MJ;Daniels J;Warren Z;Kurzius-Spencer M;Zahorodny W;Robinson Rosenberg C;White T;Durkin MS;Imm P;Nikolaou L;Yeargin-Allsopp M;Lee LC;Harrington R;Lopez M;Fitzgerald RT;Hewitt A;Pettygrove S;Constantino JN;Vehorn A;Shenouda J;Hall-Lande J;Van Naarden Braun K;Dowling NF
通讯作者：
Dowling NF
DOI：
10.1177/1362361315607724
发表时间：
2016-10
期刊：
Autism : the international journal of research and practice
影响因子：
--
作者：
Blumberg SJ;Zablotsky B;Avila RM;Colpe LJ;Pringle BA;Kogan MD
通讯作者：
Kogan MD
影响因子：
7.6
作者：
Fein, Deborah;Barton, Marianne;Tyson, Katherine
通讯作者：
Tyson, Katherine
DOI：
10.1016/j.jaac.2012.08.018
发表时间：
2012-11
影响因子：
13.3
作者：
Dawson G;Jones EJ;Merkle K;Venema K;Lowy R;Faja S;Kamara D;Murias M;Greenson J;Winter J;Smith M;Rogers SJ;Webb SJ
通讯作者：
Webb SJ