Early behavioral intervention is associated with normalized brain activity in young children with autism.
Early behavioral intervention is associated with normalized brain activity in young children with autism.
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DOI：
10.1016/j.jaac.2012.08.018
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发表时间：
2012-11
影响因子：
13.3
通讯作者：
Webb SJ
中科院分区：
文献类型：
--
作者：
Dawson G;Jones EJ;Merkle K;Venema K;Lowy R;Faja S;Kamara D;Murias M;Greenson J;Winter J;Smith M;Rogers SJ;Webb SJ
先前发表的一项随机临床试验表明，一种发育行为干预，即早期开始丹佛模型（ESDM），可以提高自闭症谱系障碍儿童的智商、语言和适应行为。本报告描述了该试验的次要结果测量，脑电图活动。48名18至30个月大的自闭症谱系障碍儿童随机接受ESDM或转介到社区干预，为期2年。干预后（48至77个月），在呈现面部和物体时测量脑电图活动（事件相关电位和频谱功率）。年龄匹配的典型儿童也进行了评估。与社区干预组相比，ESDM组在自闭症症状、智商、语言、适应和社会行为方面表现出更大的改善。ESDM组和典型儿童在观看人脸时Nc潜伏期缩短，皮层激活增加（α功率降低，θ功率增加），而社区干预组在观看物体时呈现相反的模式（事件相关电位（ERP）潜伏期缩短，皮层激活增加）。在观看人脸时，大脑皮层的激活程度越高，社交行为就越好。这是第一个证明早期行为干预与大脑活动的正常化模式有关的试验，这与患有自闭症谱系障碍的幼儿的社会行为的改善有关。
A previously published randomized clinical trial indicated that a developmental behavioral intervention, the Early Start Denver Model (ESDM), resulted in gains in IQ, language, and adaptive behavior of children with autism spectrum disorder. This report describes a secondary outcome measurement from this trial, EEG activity. Forty-eight 18- to 30-month-old children with autism spectrum disorder were randomized to receive the ESDM or referral to community intervention for 2 years. After the intervention (age 48 to 77 months), EEG activity (event-related potentials and spectral power) was measured during the presentation of faces versus objects. Age-matched typical children were also assessed. The ESDM group exhibited greater improvements in autism symptoms, IQ, language, and adaptive and social behaviors than the community intervention group. The ESDM group and typical children showed a shorter Nc latency and increased cortical activation (decreased α power and increased θ power) when viewing faces, whereas the community intervention group showed the opposite pattern (shorter latency event-related potential [ERP] and greater cortical activation when viewing objects). Greater cortical activation while viewing faces was associated with improved social behavior. This was the first trial to demonstrate that early behavioral intervention is associated with normalized patterns of brain activity, which is associated with improvements in social behavior, in young children with autism spectrum disorder.
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