Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis.
Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis.
复制标题
DOI：
10.1038/ncb2546
复制
发表时间：
2012-08
影响因子：
21.3
通讯作者：
中科院分区：
文献类型：
--
作者：
油菜素内酯（BR）和赤霉素（GA）在植物中促进许多类似的发育反应；但他们的关系尚不清楚。在这里，我们发现BR和GA通过BR激活的BZR1和GA失活的DELLA转录调控因子之间的直接相互作用而相互依赖。GA促进细胞伸长需要BR信号，而BR或活性BZR1可以抑制GA缺陷矮化表型。DELLAs在体外和体内均与BZR1直接相互作用，抑制BZR1- dna结合。全基因组分析确定了一个依赖bzr1的ga调控转录组，该转录组富含光调控基因和参与细胞壁合成和光合作用/叶绿体的基因。GA促进下胚轴伸长需要BZR1和光敏色素相互作用因子（pif）以及它们共同的下游靶点PREs。结果表明，GA释放了della介导的BZR1抑制，并且DELLA-BZR1-PIF4相互作用定义了一个核心转录模块，介导GA、BR和光信号的协调生长调节。
Brassinosteroid (BR) and gibberellin (GA) promote many similar developmental responses in plants; but their relationship remains unclear. Here we show that BR and GA act interdependently through a direct interaction between the BR-activated BZR1 and GA-inactivated DELLA transcription regulators. GA promotion of cell elongation required BR signaling, whereas BR or active BZR1 can suppresssed the GA-deficient dwarf phenotype. DELLAs directly interacted with BZR1 and inhibited BZR1-DNA binding both in vitro and in vivo. Genome-wide analysis defined a BZR1-dependent GA-regulated transcriptome, which is enriched with light-regulated genes and genes involved in cell wall synthesis and photosynthesis/chloroplast. GA promotion of hypocotyl elongation requires both BZR1 and the phytochrome interacting factors (PIFs), as well as their common downstream targets PREs. The results demonstrate that GA releases DELLA-mediated inhibition of BZR1, and that the DELLA-BZR1-PIF4 interaction defines a core transcription module that mediates coordinated growth regulation by GA, BR and light signals.
登录
查看更多内容
影响因子：
64.8
作者：
Fu, XD;Harberd, NP
通讯作者：
Harberd, NP
影响因子：
16
作者：
Kim TW;Guan S;Burlingame AL;Wang ZY
通讯作者：
Wang ZY
影响因子：
9.2
作者：
Koini, Maria A.;Alvey, Liz;Franklin, Keara A.
通讯作者：
Franklin, Keara A.
影响因子：
11.8
作者：
Hou, Xingliang;Lee, Li Yen Candy;Yu, Hao
通讯作者：
Yu, Hao
阐明植物激素信号传导整合的悖论。
影响因子：
16.8
作者：
Jaillais, Yvon;Chory, Joanne
通讯作者：
Chory, Joanne