Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.
复制标题
作者：
Foxo转录因子在细胞和生物体对营养物质及生长因子可利用性的适应过程中具有保守作用。在此我们表明，Foxo1在T细胞中具有关键的、非冗余作用。在初始T细胞中，Foxo1控制黏附分子L - 选择素、趋化因子受体CCR7以及转录因子Klf2的表达，并且其缺失足以改变淋巴细胞的运输。此外，Foxo1缺陷导致白细胞介素7受体α链（IL - 7Rα）表达出现严重缺陷，这与其结合Il7r增强子的能力相关。最后，生长因子的撤离诱导Sell、Klf2和Il7r表达出现依赖于Foxo1的增加。这些数据表明，Foxo1通过感知生长因子的可利用性并调节归巢和存活信号来调控初始T细胞的内稳态和寿命。
Foxo transcription factors have a conserved role in the adaptation of cells and organisms to nutrient and growth factor availability. Here we show that Foxo1 has a crucial, nonredundant role in T cells. In naive T cells, Foxo1 controlled the expression of the adhesion molecule L-selectin, the chemokine receptor CCR7 and the transcription factor Klf2, and its deletion was sufficient to alter lymphocyte trafficking. Furthermore, Foxo1 deficiency resulted in a severe defect in interleukin 7 receptor α-chain (IL-7Rα) expression associated with its ability to bind an Il7r enhancer. Finally, growth factor withdrawal induced a Foxo1-dependent increase in Sell, Klf2 and Il7r expression. These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals.
登录
查看更多内容
胸腺和最近的胸腺移民在维持成年外周淋巴细胞库中的作用。
影响因子：
15.3
作者：
Berzins, S P;Boyd, R L;Miller, J F
通讯作者：
Miller, J F
影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
64.5
作者：
Förster, R;Schubel, A;Lipp, M
通讯作者：
Lipp, M
影响因子：
64.8
作者：
Carlson, Corey M.;Endrizzi, Bart T.;Jameson, Stephen C.
通讯作者：
Jameson, Stephen C.