EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control.
EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control.
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DOI：
10.1371/journal.pone.0086062
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Cho ML
中科院分区：
文献类型：
--
作者：
Yang EJ;Lee J;Lee SY;Kim EK;Moon YM;Jung YO;Park SH;Cho ML
Epigallocatechin-3-gallate (EGCG) is a green tea polyphenol exerting potent anti-oxidant and anti-inflammatory effects by inhibiting signaling and gene expression. The objective of the study was to evaluate the effect of EGCG on interleukin (IL)-1 receptor antagonist knockout (IL-1RaKO) autoimmune arthritis models. IL-1RaKO arthritis models were injected intraperitoneally with EGCG three times per week after the first immunization. EGCG decreased the arthritis index and showed protective effects against joint destruction in the IL-1RaKO arthritis models. The expression of pro-inflammatory cytokines, oxidative stress proteins, and p-STAT3 (Y705) and p-STAT3 (S727), mTOR and HIF-1α were significantly lower in mice treated with EGCG. EGCG reduced osteoclast markers in vivo and in vitro along with anti-osteoclastic activity was observed in EGCG-treated IL-1RaKO mice. The proportion of Foxp3+ Treg cells increased in the spleens of mice treated with EGCG, whereas the proportion of Th17 cells reduced. In vitro, p-STAT3 (Y705) and p-STAT3 (S727), HIF1α and glycolytic pathway molecules were decreased by EGCG. EGCG suppressed the activation of mTOR and subsequently HIF-1α, which is considered as a metabolic check point of Th17/Treg differentiation supporting the therapeutic potential of EGCG in autoimmune arthritis.
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影响因子：
5.8
作者：
Singh BN;Shankar S;Srivastava RK
通讯作者：
Srivastava RK
影响因子：
3.5
作者：
Chen, Di;Pamu, Sreedhar;Cui, Qiuzhi;Chan, Tak Hang;Dou, Q. Ping
通讯作者：
Dou, Q. Ping
影响因子：
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作者：
Lin, Sze-Kwan;Shun, Chia-Tung;Liu, Chia-Ming
通讯作者：
Liu, Chia-Ming
影响因子：
4.9
作者：
Dryden, Gerald W.;Lam, Allan;McClain, Craig J.
通讯作者：
McClain, Craig J.
影响因子：
64.5
作者：
Dang EV;Barbi J;Yang HY;Jinasena D;Yu H;Zheng Y;Bordman Z;Fu J;Kim Y;Yen HR;Luo W;Zeller K;Shimoda L;Topalian SL;Semenza GL;Dang CV;Pardoll DM;Pan F
通讯作者：
Pan F