Role of the nervous system in cancers: a review.

Role of the nervous system in cancers: a review.
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DOI:
10.1038/s41420-021-00450-y
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发表时间:
2021-04-12
影响因子:
7
通讯作者:
Li G
Li G
中科院分区:
医学2区
文献类型:
--
作者:
Wang H;Zheng Q;Lu Z;Wang L;Ding L;Xia L;Zhang H;Wang M;Chen Y;Li G

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神经是肿瘤微环境的重要病理因素,包括胰腺癌、结肠癌、直肠癌、前列腺癌、头颈癌和乳腺癌。最近的研究表明,神经周围浸润与肿瘤进展和不良预后有关。反过来,肿瘤驱动神经元重新编程以吸收新的神经纤维。因此,神经与肿瘤之间的串扰是当前肿瘤研究的热点和趋势。在此,我们回顾了最近的研究,为更好地理解神经肿瘤相互作用提供了直接的支持证据。
Nerves are important pathological elements of the microenvironment of tumors, including those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent studies have associated perineural invasion with tumor progression and poor outcomes. In turn, tumors drive the reprogramming of neurons to recruit new nerve fibers. Therefore, the crosstalk between nerves and tumors is the hot topic and trend in current cancer investigations. Herein, we reviewed recent studies presenting direct supporting evidences for a better understanding of nerve–tumor interactions.
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