Closed-loop afferent electrical stimulation for recovery of hand function in individuals with motor incomplete spinal injury: early clinical results.
Closed-loop afferent electrical stimulation for recovery of hand function in individuals with motor incomplete spinal injury: early clinical results.
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闭环传入电刺激用于恢复运动不完全性脊髓损伤个体的手功能：早期临床结果。
DOI：
10.1109/embc.2016.7591007
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Sunderam,Sridhar
中科院分区：
文献类型：
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作者：
Schildt,ChristopherJ;Thomas,SarahH;Powell,ElizabethS;Sawaki,Lumy;Sunderam,Sridhar
已知传入电刺激通过使用依赖性皮层可塑性来增强康复治疗的效果。将经颅磁刺激（TMS）与外周神经刺激（PNS）配对的实验已经显示出对运动诱发电位（MEP）幅度的时间依赖性效应，这表明在闭环（CL）模式下施加的PNS可以通过正强化来增强这种效应。我们目前的早期结果，从临床试验中，脑电图脑机接口（BMI）被用来应用PNS两个主题的运动意图检测到的感觉运动皮层在线索驱动的手握任务。两名受试者均患有稳定的不完全性颈脊髓损伤（SCI），上肢功能受损与损伤水平相称。在4-6周的时间内应用CL-PNS的12个会话产生的结果表明，两个受试者的一只手的握力和EEG的任务相关调制增加，并且TMS测量的运动图面积增加。这些观察结果表明，使用这种互动疗法的康复可能会使受影响的个人受益。
Afferent electrical stimulation is known to augment the effect of rehabilitative therapy through use-dependent cortical plasticity. Experiments pairing transcranial magnetic stimulation (TMS) with peripheral nerve stimulation (PNS) have shown a timing-dependent effect on motor evoked potential (MEP) amplitude suggesting that PNS applied in closed-loop (CL) mode could augment this effect through positive reinforcement. We present early results from a clinical trial in which an EEG brain-machine interface (BMI) was used to apply PNS to two subjects in response to motor intent detected from sensorimotor cortex in a cue-driven hand grip task. Both subjects had stable incomplete cervical spinal cord injury (SCI) with impaired upper limb function commensurate with the injury level. Twelve sessions of CL-PNS applied over a 4-6 week period yielded results suggesting improved hand grip strength and increased task-related modulation of the EEG in one hand of both subjects, and increased TMS-measured motor map area in one. These observations suggest that rehabilitation using such interactive therapies could benefit affected individuals.
影响因子：
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作者：
Collinger JL;Boninger ML;Bruns TM;Curley K;Wang W;Weber DJ
通讯作者：
Weber DJ