Risk factors and laser therapy for retinopathy of prematurity in neonatal intensive care unit
Risk factors and laser therapy for retinopathy of prematurity in neonatal intensive care unit
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新生儿重症监护病房早产儿视网膜病变的危险因素及激光治疗
DOI：
10.1007/s12519-009-0058-6
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发表时间：
2009-11
影响因子：
8.7
通讯作者：
Ileana, Vatavu
中科院分区：
文献类型：
--
作者：
Zheng, Chong-Xun;Tian, Tian;Tatiana, Ciomartan;Oana, Racovitan;Ioana, Anca;Liu, Li;Ileana, Vatavu
背景随着早产儿存活率的提高，早产儿视网膜病变（ROP）的发病率也随之增高。本研究旨在探讨ROP的危险因素在新生儿重症监护室，激光治疗的影响。Methods35早产儿与各种其他疾病进行了研究。收集数据包括性别、胎龄、出生体重、母亲妊娠、Apgar评分、产前和产后缺氧、贫血、黄疸、感染、妊娠并发症和头部超声表现。所有患者均在月经后34周使用间接检眼镜进行眼底检查。将患儿分为ROP组和非ROP组。ROP患儿接受激光治疗。结果35例患儿中有27例（77.1%）有ROP，其中21例同时伴有其他疾病。激光治疗后2周和3个月的治愈率分别为74.1%和92.6%。ROP组的出生体重和胎龄均显著低于非ROP组（P<0.01）。胎龄和出生体重越低，ROP的发生率越高。出生后缺氧（P=0.013）、贫血（P = 0.012）、第二次妊娠（P<0.05）与ROP的发生率比较，经Fisher精确概率检验，差异有统计学意义（P <0.05）。结论早产儿ROP发生率高，与出生体重、孕周、产后缺氧、贫血及母亲妊娠有关，早产儿ROP的发生率随孕周的增加而增加，与出生体重、孕周、贫血及母亲妊娠有关。激光治疗显示出良好的结果。
BackgroundWith the increasing survival rates of preterm infants, the incidence of retinopathy of prematurity (ROP) is also increasing. This study aimed to investigate the risk factors for ROP in Neonatal Intensive Care Unit, and the effects of laser therapy.MethodsThirty-five premature infants with various other diseases were studied. Data were collected including gender, gestational age, birth weight, maternal gravidity, Apgar score, antenatal and postnatal hypoxia, anemia, jaundice, infection, pregnancy complications, and head ultrasound manifestations. All patients were subjected to fundus examinations at a postmenstrual age of 34 weeks using an indirect ophthalmoscope. The infants were divided into ROP group and non-ROP group. Infants with ROP received laser treatment. The data of the infants were analyzed using univariate analysis and the logistic regression model.ResultsTwenty-seven (77.1%) of the 35 infants had ROP and 21 of them also had plus diseases. The recovery rates were 74.1% and 92.6% at 2 weeks and 3 months after laser therapy, respectively. The birth weight and gestational age in the ROP group were significantly lower than those in the non-ROP group (P<0.01). The lower the gestational age and birth weight, the higher the incidence of ROP. There was a significant difference in the incidence of ROP with postnatal hypoxia (P=0.013), anemia (P=0.012) and gravidity two (P<0.05), analyzed with the Fisher’s exact probability test (P<0.05). The gestational age was significantly lower in the plus disease group than in the non-plus disease group (P<0.05).ConclusionsThe incidence of ROP is high in premature infants with various other diseases and is correlated with birth weight, gestational age, postnatal hypoxia, anemia and maternal gravidity. Laser therapy shows good outcomes.
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DOI：
10.1097/00006982-199313010-00025
发表时间：
1993
期刊：
--
影响因子：
--
作者：
McNamara Ja;W. Tasman;Gary C. Brown;J. Federman
通讯作者：
McNamara Ja;W. Tasman;Gary C. Brown;J. Federman
DOI：
10.1016/0045-9380(92)90023-r
发表时间：
1992-09
期刊：
Mead Johnson Symposium on Perinatal and Developmental Medicine
影响因子：
--
作者：
D. Phelps
通讯作者：
D. Phelps
影响因子：
--
作者：
N. Schalij-Delfos;J. Termote;B. Cats
通讯作者：
N. Schalij-Delfos;J. Termote;B. Cats
DOI：
10.1097/00006982-200202000-00009
发表时间：
2002-02
期刊：
Retina
影响因子：
--
作者：
Robert L. Steinmetz;H. Logan Brooks
通讯作者：
Robert L. Steinmetz;H. Logan Brooks
影响因子：
2.1
作者：
N. Grunauer;M. I. Sanz;A. Castanera;J. Vidal;R. González
通讯作者：
N. Grunauer;M. I. Sanz;A. Castanera;J. Vidal;R. González