Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function.
Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function.
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DOI：
10.1038/s42003-022-03405-w
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发表时间：
2022-05-16
影响因子：
5.9
通讯作者：
Pickering, Andrew M.
中科院分区：
文献类型：
--
作者：
Chocron, E. Sandra;Mdaki, Kennedy;Jiang, Nisi;Cropper, Jodie;Pickering, Andrew M.
Mitochondrial dysfunction is a key driver of diabetes and other metabolic diseases. Mitochondrial redox state is highly impactful to metabolic function but the mechanism driving this is unclear. We generated a transgenic mouse which overexpressed the redox enzyme Thioredoxin Reductase 2 (TrxR2), the rate limiting enzyme in the mitochondrial thioredoxin system. We found augmentation of TrxR2 to enhance metabolism in mice under a normal diet and to increase resistance to high-fat diet induced metabolic dysfunction by both increasing glucose tolerance and decreasing fat deposition. We show this to be caused by increased mitochondrial function which is driven at least in part by enhancements to the tricarboxylic acid cycle and electron transport chain function. Our findings demonstrate a role for TrxR2 and mitochondrial thioredoxin as metabolic regulators and show a critical role for redox enzymes in controlling functionality of key mitochondrial metabolic systems. TrxR2 overexpression in mice enhances metabolism and prevents high-fat diet induced metabolic deficits in mice through alteration in function of several enzymes in the tricarboxylic acid cycle and complexes of the electron transport chain.
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DOI：
10.1042/bj20130029
发表时间：
2013-10-15
期刊：
The Biochemical journal
影响因子：
--
作者：
Fetterman JL;Zelickson BR;Johnson LW;Moellering DR;Westbrook DG;Pompilius M;Sammy MJ;Johnson M;Dunham-Snary KJ;Cao X;Bradley WE;Zhang J;Wei CC;Chacko B;Schurr TG;Kesterson RA;Dell'italia LJ;Darley-Usmar VM;Welch DR;Ballinger SW
通讯作者：
Ballinger SW
影响因子：
2.1
作者：
Drahota, Z;Kriváková, P;Houstek, J
通讯作者：
Houstek, J
影响因子：
7.8
作者：
Pickering AM;Lehr M;Gendron CM;Pletcher SD;Miller RA
通讯作者：
Miller RA
DOI：
10.1073/pnas.1424840112
发表时间：
2015-03-17
影响因子：
11.1
作者：
Daloso, Danilo M.;Mueller, Karolin;Fernie, Alisdair R.
通讯作者：
Fernie, Alisdair R.
影响因子：
7.4
作者：
Cadenas, E;Davies, KJA
通讯作者：
Davies, KJA