Novel Methodology for Measuring Regional Myocardial Efficiency.
Novel Methodology for Measuring Regional Myocardial Efficiency.
复制标题
测量局部心肌效率的新方法。
DOI：
10.1109/tmi.2021.3065219
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发表时间：
2021-06
影响因子：
10.6
通讯作者：
Seo Y
中科院分区：
文献类型：
--
作者：
Gullberg GT;Shrestha UM;Veress AI;Segars WP;Liu J;Ordovas K;Seo Y
我们的方法不同于通常的心脏效率的全球措施，通过使用PET/MRI来测量小块心脏组织的效率，其限制大小等于PET扫描仪的空间分辨率。我们在注射15.1 mCi的11 C-醋酸盐之前立即启动了动态心脏PET研究，采集数据25分钟，同时采集MRI电影数据。1)通过利用非刚性可变形图像配准来改变Dassault Systemes FE活体心脏模型（LHM）以拟合心脏MRI电影数据中的几何形状，构建成像心脏的3D有限元（FE）生物力学模型。将具有应力、应变和功估计值的患者特定FE心脏模型转换为PET/MRI格式。2)使用1-组织隔室模型计算洗入（K1），并使用PET 11 C-醋酸盐时间活性曲线（TAC）中衰减的线性部分计算洗出k2（单）速率常数。K1用于计算血流量，k2（mono）用于计算心肌耗氧量（MVO 2）。3)使用应力和应变估计值计算心肌等效分钟功（MEMW），然后计算左心室17个组织节段的心脏效率= MEMW/MVO 2。总体MBF为0.96 ± 0.15 ml/min/gm，MVO 2范围为8 - 17 ml/100 gm/min。MRI电影数据的6个中央切片提供了0.1 - 0.4焦耳/gm/min的MEMW范围和6 - 18%的心脏效率范围。
Our approach differs from the usual global measure of cardiac efficiency by using PET/MRI to measure efficiency of small pieces of cardiac tissue whose limiting size is equal to the spatial resolution of the PET scanner. We initiated a dynamic cardiac PET study immediately prior to the injection of 15.1 mCi of 11C-acetate acquiring data for 25 minutes while simultaneously acquiring MRI cine data. 1) A 3D finite element (FE) biomechanical model of the imaged heart was constructed by utilizing nonrigid deformable image registration to alter the Dassault Systemes FE Living Heart Model (LHM) to fit the geometry in the cardiac MRI cine data. The patient specific FE cardiac model with estimates of stress, strain, and work was transformed into PET/MRI format. 2) A 1-tissue compartment model was used to calculate wash-in (K1) and the linear portion of the decay in the PET 11C-acetate time activity curve (TAC) was used to calculate the wash-out k2(mono) rate constant. K1 was used to calculate blood flow and k2 (mono) was used to calculate myocardial volume oxygen consumption (MVO2). 3) Estimates of stress and strain were used to calculate Myocardial Equivalent Minute Work (MEMW) and Cardiac Efficiency = MEMW/MVO2 was then calculated for 17 tissue segments of the left ventricle. The global MBF was 0.96 ± 0.15 ml/min/gm and MVO2 ranged from 8 to 17 ml/100gm/min. Six central slices of the MRI cine data provided a range of MEMW of 0.1 to 0.4 joules/gm/min and a range of Cardiac Efficiency of 6 to 18%.
影响因子：
2
作者：
Guclu, A.;Germans, T.;Witjas-Paalberends, E. R.;Stienen, G. J. M.;Brouwer, W. P.;Harms, H. J.;Marcus, J. T.;Vonk, A. B. A.;Stooker, W.;Yilmaz, A.;Klein, P.;ten Berg, J. M.;Kluin, J.;Asselbergs, F. W.;Lammertsma, A. A.;Knaapen, P.;van Rossum, A. C.;van der Velden, J.
通讯作者：
van der Velden, J.
影响因子：
7.6
作者：
Veress AI;Klein G;Gullberg GT
通讯作者：
Gullberg GT