One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers.
One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers.
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DOI：
10.1016/j.bbamcr.2020.118881
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Reddi AR
中科院分区：
文献类型：
--
作者：
Chambers IG;Willoughby MM;Hamza I;Reddi AR
血红素是一种疏水的含铁有机环，具有脂溶性，能与生物膜相互作用。大自然用来维持生命的血红素的性质也使其具有潜在的细胞毒性。为了在利用血红素的同时减轻其毒性，要求细胞严格控制血红素的浓度和生物利用度。从好的方面来看，可以合理地设想，与其他过渡金属类似，膜结合的转运体、可溶性载体和伴侣蛋白的组合可以协调血红素向亚细胞间的运输。然而，考虑到血红素作为过渡金属和脂质的双重性质，有必要考虑黑暗面：包括结合、隔离和控制血红素运输和生物利用度的脂类和核酸在内的非蛋白质生物分子的潜在作用。细胞器间膜接触点的出现以及来自各种细胞器的细胞内小泡的出现，增加了血红素可以通过疏水通道运输的可能性。在这篇综述中，我们的目标是集中在没有递送者的血红素传递-通过无伴侣的血红素运输途径来调节血红素动态平衡的另一种范式。
Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with biological membranes. The very same properties of heme that nature exploits to support life also renders heme potentially cytotoxic. In order to utilize heme, while also mitigating its toxicity, cells are challenged to tightly control the concentration and bioavailability of heme. On the bright side, it is reasonable to envision that, analogous to other transition metals, a combination of membrane-bound transporters, soluble carriers, and chaperones coordinate heme trafficking to subcellular compartments. However, given the dual properties exhibited by heme as a transition metal and lipid, it is compelling to consider the dark side: the potential role of non-proteinaceous biomolecules including lipids and nucleic acids that bind, sequester, and control heme trafficking and bioavailability. The emergence of inter-organellar membrane contact sites, as well as intracellular vesicles derived from various organelles, have raised the prospect that heme can be trafficked through hydrophobic channels. In this review, we aim to focus on heme delivery without deliverers - an alternate paradigm for the regulation of heme homeostasis through chaperone-less pathways for heme trafficking.
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发表时间：
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