Sequence variability at three MHC loci of finless porpoises (Neophocaena phocaenoides)
Sequence variability at three MHC loci of finless porpoises (Neophocaena phocaenoides)
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江豚 (Neophocaena phocaenoides) 三个 MHC 位点的序列变异
DOI：
10.1007/s00251-007-0223-9
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发表时间：
2007-05
期刊：
影响因子：
3.2
通讯作者：
Sun, Peng
中科院分区：
文献类型：
--
作者：
Xu, Shixia;Zhou, Kaiya;Yang, Guang;Sun, Peng
Major histocompatibility complex (MHC) class IIDQBandDRAgenes and class I gene of finless porpoises (Neophocaena phocaenoides) were investigated by single-strand conformation polymorphism and sequence analysis. TheDRA,DQB, and MHC-I loci each contained 5, 14, and 34 unique sequences, respectively, and considerable sequence variation was found at the MHC-I andDQBloci. Gene duplication was manifested as three to five distinct sequences at each of theDQBand MHC-I loci from some individuals, and these sequences at each of the two loci separately clustered into four groups (cluster A, B, C, and D) based on the phylogenetic trees. Phylogenetic reconstruction revealed a trans-species pattern of evolution. Relatively high rates of non-synonymous (dN) vs synonymous (dS) substitution in the peptide-binding region (PBR) suggested balancing selection for maintaining polymorphisms at the MHC-I andDQBloci. In contrast, one single locus with little sequence variation was detected in theDRAgene, and no non-synonymous substitutions in the PBR indicated no balancing selection on this gene.
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影响因子：
3.3
作者：
P. Hedrick;K. M. Parker;Ellen L. Miller;P. Miller
通讯作者：
P. Hedrick;K. M. Parker;Ellen L. Miller;P. Miller
影响因子：
8.7
作者：
J. Klein;N. Takahata
通讯作者：
J. Klein;N. Takahata
影响因子：
1.9
作者：
Miki Shirakihara;K. Shirakihara;A. Takemura
通讯作者：
Miki Shirakihara;K. Shirakihara;A. Takemura
影响因子：
56.9
作者：
Harvell, CD;Kim, K;Vasta, GR
通讯作者：
Vasta, GR
DOI：
10.1644/1545-1542(2001)082
发表时间：
2001-05
期刊：
--
影响因子：
--
作者：
Clara Stefen
通讯作者：
Clara Stefen