Endogenous activity modulates stimulus and circuit-specific neural tuning and predicts perceptual behavior
Endogenous activity modulates stimulus and circuit-specific neural tuning and predicts perceptual behavior
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内源性活动调节刺激和特定电路的神经调节并预测感知行为
DOI：
10.1038/s41467-020-17729-w
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发表时间：
2020
影响因子：
16.6
通讯作者：
Ghuman, Avniel Singh
中科院分区：
文献类型：
--
作者：
Li, Yuanning;Ward, Michael J.;Richardson, R. Mark;G’Sell, Max;Ghuman, Avniel Singh
知觉不仅反映感觉输入，而且反映这些输入进入大脑时的内源性状态。先前的研究表明，内源性神经状态通过非特异性的全局机制（如唤醒的自发波动）影响刺激处理。目前还不清楚内源性活动是否也会影响回路和刺激特异性加工和行为。在这里，我们使用30名手术前癫痫患者的颅内记录来表明，内源性活动模式与不同视觉类别选择性神经回路中逐个试验神经调谐的强度相关。与特定神经回路调谐相关的内源性活动的相同方面也与仅针对来自该回路所选择的类别的刺激的行为反应时间相关。这些结果表明，内源性活动可以调节神经调谐和影响行为的电路和刺激特异性的方式，反映了一个潜在的机制，内源性神经状态促进和偏见的看法。
Perception reflects not only sensory inputs, but also the endogenous state when these inputs enter the brain. Prior studies show that endogenous neural states influence stimulus processing through non-specific, global mechanisms, such as spontaneous fluctuations of arousal. It is unclear if endogenous activity influences circuit and stimulus-specific processing and behavior as well. Here we use intracranial recordings from 30 pre-surgical epilepsy patients to show that patterns of endogenous activity are related to the strength of trial-by-trial neural tuning in different visual category-selective neural circuits. The same aspects of the endogenous activity that relate to tuning in a particular neural circuit also correlate to behavioral reaction times only for stimuli from the category that circuit is selective for. These results suggest that endogenous activity can modulate neural tuning and influence behavior in a circuit- and stimulus-specific manner, reflecting a potential mechanism by which endogenous neural states facilitate and bias perception.
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影响因子：
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