Endoscopic ultrasonography with fine-needle aspiration for histological diagnosis of solid pancreatic masses: a meta-analysis of diagnostic accuracy studies.
Endoscopic ultrasonography with fine-needle aspiration for histological diagnosis of solid pancreatic masses: a meta-analysis of diagnostic accuracy studies.
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DOI：
10.1186/s12876-016-0519-z
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发表时间：
2016-08-31
影响因子：
2.4
通讯作者：
Zhu L
中科院分区：
文献类型：
--
作者：
Banafea O;Mghanga FP;Zhao J;Zhao R;Zhu L
既往研究表明，内镜超声细针抽吸术（EUS-FNA）是诊断胰腺病变的可靠工具；然而，不同研究报告的敏感性和特异性差异很大。本研究的目的是汇集现有文献并评估 EUS-FNA 在诊断胰腺实性病变中的整体性能。对 MEDLINE、Cochrane 系统评价数据库和 EMBASE 进行系统检索，以识别 1995 年 1 月至 2014 年 1 月期间发表的原创文章和评论文章，这些文章报告了 EUS-FNA 在胰腺肿块诊断中的准确性。使用诊断准确性研究评分工具的质量评估来评估纳入研究的质量。 Meta-DiSc 软件用于计算汇总敏感性和特异性、阳性和阴性似然比，并构建汇总的受试者工作特征曲线。该研究纳入了 20 项研究，总共涉及 2,761 名患者。 EUS-FNA 诊断胰腺实性病变的汇总敏感性和特异性分别为 90.8% [95% 置信区间 (CI)，89.4–92%] 和 96.5%（95% CI，94.8–97.7%）。阳性和阴性似然比分别为 14.8 (95% CI, 8.0–27.3) 和 0.12 (95% CI, 0.09–0.16)。总体诊断准确率为 91.0%。我们的研究结果表明，EUS-FNA 在诊断胰腺实性病变方面具有较高的敏感性和特异性。
Previous studies have demonstrated that endoscopic ultrasound-fine needle aspiration (EUS-FNA) is a reliable tool for diagnosing pancreatic lesions; however, the reported sensitivity and specificity vary greatly across studies. The aim of this study was to pool the existing literature and assess the overall performance of EUS-FNA in the diagnosis of solid pancreatic lesions. A systematic search of MEDLINE, Cochrane Database for Systematic Reviews, and EMBASE was performed to identify original and review articles published between January 1995 and January 2014 that reported the accuracy of EUS-FNA in the diagnosis of pancreatic masses. Quality of the included studies was assessed using the quality assessment of diagnosis accuracy studies score tool. Meta-DiSc software was used to calculate the pooled sensitivity and specificity, positive and negative likelihood ratios, and to construct the summary receiver operating characteristics curve. Twenty studies involving a total of 2,761 patients were included in the study. The pooled sensitivity and specificity of EUS-FNA in the diagnosis of solid pancreatic lesions were 90.8 % [95 % confidence interval (CI), 89.4–92 %] and 96.5 % (95 % CI, 94.8–97.7 %), respectively. The positive and negative likelihood ratios were 14.8 (95 % CI, 8.0–27.3) and 0.12 (95 % CI, 0.09–0.16), respectively. The overall diagnostic accuracy was 91.0 %. Our findings suggest that EUS-FNA has high sensitivity and specificity in the diagnosis of solid pancreatic lesions.
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影响因子：
2.9
作者：
Cherian, P. Thomas;Mohan, Prasoon;Mahon, Brinder S.
通讯作者：
Mahon, Brinder S.
影响因子：
3.4
作者：
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9.8
作者：
Agarwal, B;Abu-Hamda, E;Ho, L
通讯作者：
Ho, L
影响因子：
3.2
作者：
Raut, CP;Grau, AJ;Evans, DB
通讯作者：
Evans, DB
影响因子：
6.3
作者：
Hikichi, Takuto;Irisawa, Atsushi;Obara, Katsutoshi
通讯作者：
Obara, Katsutoshi