Biological characteristics of IL-6 and related intestinal diseases.

Biological characteristics of IL-6 and related intestinal diseases.
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IL-6生物学特性与相关肠道疾病

DOI:
10.7150/ijbs.51362
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发表时间:
2021
影响因子:
9.2
通讯作者:
Xu JD
Xu JD
中科院分区:
生物学2区
文献类型:
--
作者:
Guo Y;Wang B;Wang T;Gao L;Yang ZJ;Wang FF;Shang HW;Hua R;Xu JD

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肠道是人体重要的消化器官和最大的免疫器官。白细胞介素-6(IL-6)是多种途径的重要介质,参与不同类型细胞之间的相互作用,与肠道的生理和病理状况密切相关。本文就IL-6的信号通路及其在维持肠道内环境稳定中的作用作一综述。我们还探讨了它与神经系统的关系,并强调了它在帕金森病中的潜在作用。本文根据其对肠道肿瘤和炎症双重作用的特殊性,总结了二者是如何通过独特的过程来实现的。
The intestine serves as an important digestive and the largest immune organ in the body. Interleukin-6(IL-6), an important mediator of various pathways, participates in the interactions between different kinds of cells and closely correlates with intestinal physiological and pathological condition. In this review we summarize the signaling pathways of IL-6 and its functions in maintaining intestinal homeostasis. We also explored its relation with nervous system and highlight its potential role in Parkinson's disease. Based on its specialty of the double-side influences on intestinal tumors and inflammation, we summarize how they are done through distinctive process.
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