The Multiple Functions of B Cells in Chronic HBV Infection.
The Multiple Functions of B Cells in Chronic HBV Infection.
复制标题
B 细胞在慢性 HBV 感染中的多种功能。
DOI：
10.3389/fimmu.2020.582292
复制
发表时间：
2020
影响因子：
7.3
通讯作者：
Yin W
中科院分区：
文献类型：
--
作者：
Cai Y;Yin W
慢性B型肝炎病毒（HBV）感染是导致肝脏疾病的主要原因之一，其自然史和临床转归与B细胞的作用密切相关。作为体液免疫细胞，B细胞在产生抗HBV抗体的过程中起关键作用。此外，一些研究还表征了参与抗原呈递和调节抗体分泌以外的免疫应答的其他B细胞亚群。然而，并非所有的B细胞亚群在慢性HBV感染的免疫应答中发挥积极作用，各种B细胞亚群共同介导持续HBV感染、耐受和肝损伤。因此，我们进一步试图阐明B细胞的多种功能，以获得对慢性乙型肝炎（CHB）发病机制的理解的新见解。我们还回顾了目前针对B细胞的免疫治疗，以探索治疗慢性HBV感染的新的治疗干预措施。
Chronic hepatitis B virus (HBV) infection is one of the main causes of liver diseases, of which the natural history and clinical outcomes are associated with the role of B cells. As humoral immune cells, B cells play a critical role in the process of anti-HBV antibody production. In addition, some studies have also characterized other B cell subsets involved in antigen presentation and regulating the immune response beyond antibody secretion. However, not all B cell subsets play a positive role in the immune response to chronic HBV infection, and various B cell subsets jointly mediate persistent HBV infection, tolerance, and liver damage. Thus, we further sought to elucidate the multiple functions of B cells to gain novel insight into the understanding of chronic hepatitis B (CHB) pathogenesis. We also reviewed the current immunotherapies targeting B cells to explore novel therapeutic interventions for the treatment of chronic HBV infection.
影响因子：
2
作者：
Mohamadkhani A;Naderi E;Sotoudeh M;Katoonizadeh A;Montazeri G;Poustchi H
通讯作者：
Poustchi H