Comparison of the Adrenal and Renal Responses to Angiotensin II in Fetal Lambs and Adult Sheep
Comparison of the Adrenal and Renal Responses to Angiotensin II in Fetal Lambs and Adult Sheep
复制标题
胎羔和成年绵羊肾上腺和肾脏对血管紧张素 II 反应的比较
作者：
J. Robillard;R. A. Gomez;D. Vanorden;F. Smith
在长期插管的胎羊（妊娠112-131天;足月145天）和成年非妊娠绵羊中研究了肾上腺和肾脏对血浆血管紧张素II（All）类似增加的反应。调整All输注速率，以比较胎儿和成年母羊之间血浆AH浓度相似升高的影响。在两个胎儿中，血浆中的所有升高均与血浆肾素活性（PRA）降低相关。（5.55 ± 1.53 ~ 2.11 ± 0.59ng/ml/hr，P < 0.05），成年母羊（1.28 ± 0.34 ~ 0.62 ± 0.16ng/ml/hr，P< 0.05），但胎羊与成年母羊相比，血浆中PRA的百分比变化无显著性差异。相反，所有PRA的影响，血浆中所有的增加并没有产生平行的血浆醛固酮浓度的变化时，胎儿相比，成年母羊。成年母羊血浆醛固酮浓度变化百分率（+165 ± 37%）显著高于胎儿（+58 ± 15%）（P < 0.01）。最后，当成年母羊血浆中A11浓度达到最高时，胎儿尿中PGE和PGF_（2a）的排泄量显著增加（P < 0.05）。总之，目前的结果倾向于表明，胎儿和成年母羊之间的差异，在所有的反应，反应较小的胎儿。
The adrenal and renal responses to similar increases in plasma angiotensin II (All) were studied in chronically catheterized fetal lambs (112–131 days gestation; term 145 days) and adult nonpregnant sheep. The rate of All infusion was adjusted to compare the effect of similar rises in plasma AH concentration between fetuses and adult ewes. Increases in plasma All were associated with a decrease in plasma renin activity (PRA) in both fetuses (5.55 ± 1.53 to 2.11 ± 0.59 ng/ml per hr, P < 0.05) and adult ewes (1.28 ± 0.34 to 0.62 ± 0.16 ng/ml per hr, P< 0.05), but the percent changes in PRA for similar increases in plasma All were not different when fetuses were compared to adult ewes. Contrary to the effect of All on PRA, the increase in plasma All did not produce parallel changes in plasma aldosterone concentration when fetuses were compared to adult ewes. The percent changes in plasma aldosterone concentration for similar increases in All concentration were significantly higher in adult ewes (+165 ± 37%) than in fetuses (+58 ± 15%) (P < 0.01). Finally, there were no significant changes in fetal urinary excretion of PGE and PGF2a when a significant rise (P < 0.05) was observed in adult ewes at the highest level of plasma All concentration. In summary, the present results tend to suggest that there are differences between fetuses and adult ewes in the response to All, the response being smaller in fetuses.
抑制前列腺素合成对胎儿肾功能的影响。
影响因子：
19.6
作者：
Matson,JR;Stokes,JB;Robillard,JE
通讯作者：
Robillard,JE
醛固酮对胎儿期和新生儿期肾脏钠和钾排泄的作用。
DOI：
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发表时间：
1980
期刊：
Developmental pharmacology and therapeutics
影响因子：
--
作者：
Robillard,JE;Ramberg,E;Sessions,C;Consamus,B;VanOrden,D;Weismann,D;SmithJr,FG
通讯作者：
SmithJr,FG