Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery.
Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery.
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DOI：
10.1177/1744806916683182
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发表时间：
2016-01
期刊：
影响因子：
3.3
通讯作者：
Ikeda K
中科院分区：
文献类型：
--
作者：
Muraoka W;Nishizawa D;Fukuda K;Kasai S;Hasegawa J;Wajima K;Nakagawa T;Ikeda K
芬太尼经常被用来代替吗啡用于治疗疼痛，因为它的副作用较少。已知吗啡通过葡萄糖醛酸化的代谢受UGT 2B7基因多态性的影响。据报道，芬太尼的一些代谢产物通过葡萄糖醛酸结合代谢。参与芬太尼代谢途径的基因也可能影响芬太尼敏感性。我们分析了芬太尼敏感性和UGT 2B7基因多态性之间的关联，以阐明芬太尼敏感性个体差异的遗传决定因素。本研究通过标准化疼痛测试和芬太尼需求来评估接受统一手术的健康日本受试者，检查UGT 2B 7基因的单核苷酸多态性（SNP）是否影响冷痛敏感性和芬太尼的镇痛作用。据报道，UGT2B7的rs7439366 SNP与吗啡的代谢和镇痛作用相关。我们发现，这种SNP也与芬太尼在冷加压诱导疼痛试验中的镇痛作用有关。提示rs7439366 SNP的C等位基因可能增强镇痛效果。UGT 2B7的两个SNPs rs4587017和rs1002849也被发现是可能影响芬太尼在冷压诱发疼痛试验中的镇痛作用的新SNPs。芬太尼对冷压诱发疼痛的敏感性与UGT 2B7基因的rs7439366、rs4587017和rs1002849 SNP相关。我们的研究结果可能为实现满意的疼痛控制提供有价值的信息，并为个性化疼痛治疗开辟新的途径。
Fentanyl is often used instead of morphine for the treatment of pain because it has fewer side effects. The metabolism of morphine by glucuronidation is known to be influenced by polymorphisms of the UGT2B7 gene. Some metabolic products of fentanyl are reportedly metabolized by glucuronate conjugation. The genes that are involved in the metabolic pathway of fentanyl may also influence fentanyl sensitivity. We analyzed associations between fentanyl sensitivity and polymorphisms of the UGT2B7 gene to clarify the hereditary determinants of individual differences in fentanyl sensitivity. This study examined whether single-nucleotide polymorphisms (SNPs) of the UGT2B7 gene affect cold pain sensitivity and the analgesic effects of fentanyl, evaluated by a standardized pain test and fentanyl requirements in healthy Japanese subjects who underwent uniform surgical procedures. The rs7439366 SNP of UGT2B7 is reportedly associated with the metabolism and analgesic effects of morphine. We found that this SNP is also associated with the analgesic effects of fentanyl in the cold pressor-induced pain test. It suggested that the C allele of the rs7439366 SNP may enhance analgesic efficacy. Two SNPs of UGT2B7, rs4587017 and rs1002849, were also found to be novel SNPs that may influence the analgesic effects of fentanyl in the cold pressor-induced pain test. Fentanyl sensitivity for cold pressor-induced pain was associated with the rs7439366, rs4587017, and rs1002849 SNPs of the UGT2B7 gene. Our findings may provide valuable information for achieving satisfactory pain control and open to new avenues for personalized pain treatment.
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影响因子：
11
作者：
Nishizawa, D.;Fukuda, K.;Kasai, S.;Hasegawa, J.;Aoki, Y.;Nishi, A.;Saita, N.;Koukita, Y.;Nagashima, M.;Katoh, R.;Satoh, Y.;Tagami, M.;Higuchi, S.;Ujike, H.;Ozaki, N.;Inada, T.;Iwata, N.;Sora, I.;Iyo, M.;Kondo, N.;Won, M-J;Naruse, N.;Uehara-Aoyama, K.;Itokawa, M.;Koga, M.;Arinami, T.;Kaneko, Y.;Hayashida, M.;Ikeda, K.
通讯作者：
Ikeda, K.
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
2.5
作者：
Martikainen, IK;Närhi, MV;Pertovaara, A
通讯作者：
Pertovaara, A
影响因子：
7.4
作者：
Bisgaard, T;Klarskov, B;Kehlet, H
通讯作者：
Kehlet, H
影响因子：
3.5
作者：
Moriyama, Ayako;Nishizawa, Daisuke;Ikeda, Kazutaka
通讯作者：
Ikeda, Kazutaka