Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin.
Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin.
复制标题
编码人类细胞粘附分子 uvomorulin 的基因的表征和染色体定位。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
R. Kemler
中科院分区：
文献类型：
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作者：
A. Mansouri;N. Spurr;P. Goodfellow;R. Kemler
我们已经分离出一个约2.0 kb的人cDNA克隆，其中含有人细胞粘附分子uvomorulin的编码序列。人和小鼠cDNA的比较显示广泛的同源性为82%的核苷酸和83%的推导的氨基酸序列。这两个cDNA共同的结构特征表明，uvomorulin在哺乳动物中进化高度保守，并强调其在组织发生中的功能重要性。此外，使用人x小鼠体细胞杂交，将人uvomorulin基因定位于16号染色体16 p11 - 16 qter区域。
We have isolated an approximately 2.0-kb human cDNA clone containing coding sequences for the human cell adhesion molecule, uvomorulin. Comparison of human and mouse cDNA revealed extensive homology of 82% for the nucleotide and 83% for the deduced amino acid sequence. This and other structural features common to both cDNAs demonstrate that uvomorulin is evolutionarily highly conserved in mammals and underline its functional importance in histogenesis. Moreover, with the use of human x mouse somatic-cell hybrids, the human uvomorulin gene was localized on chromosome 16, in the region 16p11-16qter.
影响因子：
2.7
作者：
DAMJANOV, I;DAMJANOV, A;DAMSKY, CH
通讯作者：
DAMSKY, CH