Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells.
Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells.
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DOI：
10.3390/molecules14104166
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发表时间：
2009-10-19
期刊：
影响因子：
--
通讯作者：
Dong JH
中科院分区：
文献类型：
--
作者：
Chang S;Yin SL;Wang J;Jing YK;Dong JH
A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl]acryla- mide(12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571.
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DOI：
10.1002/cber.19640971220
发表时间：
1964-01-01
期刊：
CHEMISCHE BERICHTE-RECUEIL
影响因子：
--
作者：
BREDERECK, H;EFFENBERGER, F;BOTSCH, H
通讯作者：
BOTSCH, H
影响因子：
20.3
作者：
Roche-Lestienne, C;Soenen-Cornu, V;Preudhomme, C
通讯作者：
Preudhomme, C
影响因子：
11.4
作者：
Hochhaus, A;Kreil, S;Hehlmann, R
通讯作者：
Hehlmann, R
影响因子：
7.3
作者：
Thomsen, Rene;Christensen, Mikael H.
通讯作者：
Christensen, Mikael H.
影响因子：
64.8
作者：
ROWLEY, JD
通讯作者：
ROWLEY, JD