Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.
Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.
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DOI：
10.1016/j.ejca.2009.06.011
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发表时间：
2009-12
影响因子：
8.4
通讯作者：
Bishop, Julia A. Newton
中科院分区：
文献类型：
--
作者：
Randerson-Moor, Juliette A.;Taylor, John C.;Elliott, Faye;Chang, Yu-Mei;Beswick, Samantha;Kukalizch, Kairen;Affleck, Paul;Leake, Susan;Haynes, Sue;Karpavicius, Birute;Marsden, Jerry;Gerry, Edwina;Bale, Linda;Bertram, Chandra;Field, Helen;Barth, Julian H.;Silva, Isabel dos Santos;Swerdlow, Anthony;Kanetsky, Peter A.;Barrett, Jennifer H.;Bishop, D. Timothy;Bishop, Julia A. Newton
We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D3 levels in order to investigate the role of vitamin D in melanoma susceptibility. There was no significant evidence of an association between any VDR SNP and risk in 1028 population-ascertained cases and 402 controls from Leeds, UK. In a second Leeds case-control study (299 cases and 560 controls) the FokI T allele was associated with increased melanoma risk (OR 1.42, 95% CI 1.06-1.91, p=0.02). In a meta-analysis in conjunction with published data from other smaller data sets (total 3769 cases and 3636 controls), the FokI T allele was associated with increased melanoma risk (odds ratio (OR) 1.19, 95% confidence interval (CI) 1.05-1.35), and the BsmI A allele was associated with a reduced risk (OR 0.81, 95% CI 0.72-0.92), in each instance under a parsimonious dominant model. In the first Leeds case-control comparison cases were more likely to have a higher body mass index (BMI) than controls (p=0.007 for linear trend). There was no evidence of a case-control difference in serum 25-hydroxyvitamin D3 levels. In 1043 incident cases from the first Leeds case-control study, a single estimation of serum 25-hydroxyvitamin D3 level taken at recruitment was inversely correlated with Breslow thickness (p=0.03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression.
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DOI：
10.1093/jnci/dji019
发表时间：
2005-02-02
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Berwick, M;Armstrong, BK;Barnhill, R
通讯作者：
Barnhill, R
影响因子：
6.4
作者：
BLISS, JM;FORD, D;EASTON, DF
通讯作者：
EASTON, DF
影响因子：
8.4
作者：
Gandini, Sara;Raimondi, Sara;Testori, Alessandro
通讯作者：
Testori, Alessandro
影响因子：
4.7
作者：
Han, Jiali;Colditz, Graham A.;Hunter, David J.
通讯作者：
Hunter, David J.
英格兰约克郡地区皮肤恶性黑色素瘤的最新趋势； 1993 - 2003年，与疾病阶段有关的发病率，死亡率和生存率。
影响因子：
8.8
作者：
Downing, A;Newton-Bishop, J A;Forman, D
通讯作者：
Forman, D