BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity.
BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity.
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DOI：
10.3389/fimmu.2021.692729
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发表时间：
2021
影响因子：
7.3
通讯作者：
Ooi JD
中科院分区：
文献类型：
--
作者：
Eggenhuizen PJ;Ng BH;Chang J;Fell AL;Cheong RMY;Wong WY;Gan PY;Holdsworth SR;Ooi JD
流行病学研究和临床试验表明，卡介苗（BCG）疫苗对2019冠状病毒病（COVID-19）具有保护作用。目前有30多项临床试验评估卡介苗接种是否可以预防或减轻COVID-19的严重程度。然而，BCG疫苗接种可诱导严重急性呼吸综合征冠状病毒2（SARS-CoV-2）特异性T细胞应答的机制尚不清楚。在这里，我们确定了8个新的BCG衍生肽与SARS-CoV-2 NSP 3或NSP 13衍生肽具有显着的序列同源性。使用体外共培养系统，我们表明，人的CD 4+和CD 8 + T细胞与BCG衍生的肽开发增强其相应的同源SARS-CoV-2衍生的肽的反应性。正如预期的那样，个体之间的HLA差异意味着并非所有人都对所有8种BCG衍生肽产生免疫原性应答。然而，所有20个用BCG衍生肽引发的个体都对8种SARS-CoV-2衍生肽中的至少7种产生了增强的T细胞反应性。这些发现提供了一种体外机制，可以部分解释BCG疫苗接种对COVID-19具有一定保护作用的流行病学观察结果。
Epidemiological studies and clinical trials suggest Bacillus Calmette-Guérin (BCG) vaccine has protective effects against coronavirus disease 2019 (COVID-19). There are now over 30 clinical trials evaluating if BCG vaccination can prevent or reduce the severity of COVID-19. However, the mechanism by which BCG vaccination can induce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses is unknown. Here, we identify 8 novel BCG-derived peptides with significant sequence homology to either SARS-CoV-2 NSP3 or NSP13-derived peptides. Using an in vitro co-culture system, we show that human CD4+ and CD8+ T cells primed with a BCG-derived peptide developed enhanced reactivity to its corresponding homologous SARS-CoV-2-derived peptide. As expected, HLA differences between individuals meant that not all persons developed immunogenic responses to all 8 BCG-derived peptides. Nevertheless, all of the 20 individuals that were primed with BCG-derived peptides developed enhanced T cell reactivity to at least 7 of 8 SARS-CoV-2-derived peptides. These findings provide an in vitro mechanism that may account, in part, for the epidemiologic observation that BCG vaccination confers some protection from COVID-19.
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DOI：
10.1056/nejmoa1714021
发表时间：
2018-07-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Nemes E;Geldenhuys H;Rozot V;Rutkowski KT;Ratangee F;Bilek N;Mabwe S;Makhethe L;Erasmus M;Toefy A;Mulenga H;Hanekom WA;Self SG;Bekker LG;Ryall R;Gurunathan S;DiazGranados CA;Andersen P;Kromann I;Evans T;Ellis RD;Landry B;Hokey DA;Hopkins R;Ginsberg AM;Scriba TJ;Hatherill M;C-040-404 Study Team
通讯作者：
C-040-404 Study Team
影响因子：
4.4
作者：
Raué, HP;Brien, JD;Slifka, MK
通讯作者：
Slifka, MK
影响因子：
15.9
作者：
Noval Rivas, Magali;Ebinger, Joseph E.;Arditi, Moshe
通讯作者：
Arditi, Moshe
影响因子：
100.3
作者：
Goodridge, Helen S.;Ahmed, S. Sohail;Wilson, Christopher B.
通讯作者：
Wilson, Christopher B.
影响因子：
5.4
作者：
Mathurin, Keisha S.;Martens, Gregory W.;Welsh, Raymond M.
通讯作者：
Welsh, Raymond M.