Concise Review: Salivary Gland Regeneration: Therapeutic Approaches from Stem Cells to Tissue Organoids.
Concise Review: Salivary Gland Regeneration: Therapeutic Approaches from Stem Cells to Tissue Organoids.
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DOI：
10.1002/stem.2455
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Ferreira JN
中科院分区：
文献类型：
--
作者：
Lombaert I;Movahednia MM;Adine C;Ferreira JN
人类唾液腺（SG）具有上皮腺泡的优雅结构，连接导管分支结构、血管和神经元网络，它们共同起产生和分泌唾液的作用。这篇评论的重点是翻译的细胞和组织为基础的研究，对患者的治疗患有SG功能减退和相关的口干综合征（口干），由于放射治疗或全身性疾病。我们将广泛地回顾最近的文献，并讨论干/祖细胞和组织为基础的治疗SG修复和/或再生的临床前景。到目前为止，已经提出了几种策略来恢复SG功能：（1）移植自体SG衍生的上皮干/祖细胞;（2）利用非上皮细胞和/或其生物活性裂解物;和（3）组织工程方法，使用载有SG细胞和/或生物活性线索的3D（三维）生物材料来模拟体内SG。我们预测，这些领域的进一步科学改进将转化为有效的治疗方法，用于修复受损的腺体和开发微型SG类器官，以从根本上恢复唾液分泌。
The human salivary gland (SG) has an elegant architecture of epithelial acini, connecting ductal branching structures, vascular and neuronal networks that together function to produce and secrete saliva. This review focuses on the translation of cell- and tissue-based research toward therapies for patients suffering from SG hypofunction and related dry mouth syndrome (xerostomia), as a consequence of radiation therapy or systemic disease. We will broadly review the recent literature and discuss the clinical prospects of stem/progenitor cell and tissue-based therapies for SG repair and/or regeneration. Thus far, several strategies have been proposed for the purpose of restoring SG function: (1) transplanting autologous SG-derived epithelial stem/progenitor cells; (2) exploiting nonepithelial cells and/or their bioactive lysates; and (3) tissue engineering approaches using 3D (three-dimensional) biomaterials loaded with SG cells and/or bioactive cues to mimic in vivo SGs. We predict that further scientific improvement in each of these areas will translate to effective therapies toward the repair of damaged glands and the development of miniature SG organoids for the fundamental restoration of saliva secretion.
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DOI：
10.1158/1078-0432.ccr-11-0179
发表时间：
2011-12-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Banh A;Xiao N;Cao H;Chen CH;Kuo P;Krakow T;Bavan B;Khong B;Yao M;Ha C;Kaplan MJ;Sirjani D;Jensen K;Kong CS;Mochly-Rosen D;Koong AC;Le QT
通讯作者：
Le QT
影响因子：
45.3
作者：
Brizel, DM;Wasserman, TH;Sauer, R
通讯作者：
Sauer, R
影响因子：
2.7
作者：
Bullard, Tara;Koek, Laurie;Ovitt, Catherine E.
通讯作者：
Ovitt, Catherine E.
影响因子：
4
作者：
Hai, Bo;Yang, Zhenhua;Liu, Fei
通讯作者：
Liu, Fei
影响因子：
11.8
作者：
Aure, Marit H.;Konieczny, Stephen F.;Ovitt, Catherine E.
通讯作者：
Ovitt, Catherine E.