Asthma Exacerbations: The Genes Behind the Scenes.
Asthma Exacerbations: The Genes Behind the Scenes.
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DOI：
10.18176/jiaci.0878
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发表时间：
2023-04-18
影响因子：
7.2
通讯作者：
Pino-Yanes, M.
中科院分区：
文献类型：
--
作者：
Herrera-Luis, E.;Forno, E.;Celedon, J. C.;Pino-Yanes, M.
The clinical and socioeconomic burden of asthma exacerbations (AEs) represents a major public health problem. In the last four years, there has been an increase in ethnic diversity in candidate-gene and genome-wide association studies (GWAS) of AEs, which in the latter case has led to the identification of novel genes and underlying pathobiological processes. Pharmacogenomics, admixture mapping analyses, and the combination of multiple “omic” layers have contributed to prioritizing genomic regions of interest and/or understanding the functional consequences of genetic variation. Despite this, the field still lags behind the genomics of asthma, where a vast compendium of genetic approaches has been used (e.g., gene-environment interactions, next-generation sequencing, or polygenic risk scores). Furthermore, the roles of the DNA methylome and histone modifications in AEs have been scarcely investigated, and microRNA findings remain to be validated in independent studies. Likewise, the most recent transcriptomic studies highlight the importance of host-airway microbiome interaction in the modulation of AEs risk. Leveraging -omics and deep-phenotyping data from sub-types or homogenous subgroups of patients will be crucial to overcome the inherent heterogeneity of AEs, and boost the identification of potential therapeutic targets and the implementation of precision medicine in clinical practice for AEs.
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影响因子：
7.3
作者：
Cañas JA;Rodrigo-Muñoz JM;Sastre B;Gil-Martinez M;Redondo N;Del Pozo V
通讯作者：
Del Pozo V
影响因子：
5.9
作者：
Chorley BN;Atabakhsh E;Doran G;Gautier JC;Ellinger-Ziegelbauer H;Jackson D;Sharapova T;Yuen PST;Church RJ;Couttet P;Froetschl R;McDuffie J;Martinez V;Pande P;Peel L;Rafferty C;Simutis FJ;Harrill AH
通讯作者：
Harrill AH
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影响因子：
16.6
作者：
Ahluwalia TS;Eliasen AU;Sevelsted A;Pedersen CT;Stokholm J;Chawes B;Bork-Jensen J;Grarup N;Pedersen O;Hansen T;Linneberg A;Sharma A;Weiss ST;Evans MD;Jackson DJ;Morin A;Krogfelt KA;Schjørring S;Mortensen PB;Hougaard DM;Bybjerg-Grauholm J;Bækvad-Hansen M;Mors O;Nordentoft M;Børglum AD;Werge T;Agerbo E;Gern JE;Lemanske RF Jr;Ober C;Pedersen AG;Bisgaard H;Bønnelykke K
通讯作者：
Bønnelykke K
DOI：
10.1016/j.jaci.2014.05.037
发表时间：
2014-09
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Akinbami LJ;Moorman JE;Simon AE;Schoendorf KC
通讯作者：
Schoendorf KC
影响因子：
30.8
作者：
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通讯作者：
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