Nucleases as molecular targets for cancer diagnosis.
Nucleases as molecular targets for cancer diagnosis.
复制标题
核酸酶是用于癌症诊断的分子靶标。
DOI：
10.1186/s40364-021-00342-4
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发表时间：
2021-11-22
影响因子：
11.1
通讯作者：
Hernandez FJ
中科院分区：
文献类型：
--
作者：
Balian A;Hernandez FJ
早期癌症诊断是改善治疗选择和提高生存率的关键因素。为了寻找性能更好的癌症诊断生物标志物，人们付出了巨大的研究努力。然而，由于用于早期诊断的高精度新型生物标志物仍然是一个未满足的临床需求，人们的探索仍在继续。核酸酶是能够切割核酸的酶，长期以来一直被认为是潜在的癌症生物标志物。核酸酶的影响对于生物功能至关重要，它们在不同细胞对应物中的存在和催化活性引发了人们对研究核酸酶作为有前途的癌症生物标志物的作用的热情。然而，这些蛋白质最本质的特征，即它们的酶活性，尚未得到充分利用。这篇综述讨论了作为癌症生物标志物的核酸酶，提供了对其生理作用的一瞥。此外，它强调了利用癌症相关核酸酶的酶活性作为使用核酸探针作为底物的新型诊断生物标志物的潜力。
Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The implications of nucleases are key for biological functions, their presence in different cellular counterparts and catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers. However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. This review discusses nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, it highlights the potential of harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates.
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影响因子：
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