On the classification of long non-coding RNAs.
On the classification of long non-coding RNAs.
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DOI：
10.4161/rna.24604
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发表时间：
2013-06
期刊：
影响因子：
4.1
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Ma L;Bajic VB;Zhang Z
已发现长链非编码RNA（lncRNA）在多种重要的生物过程中执行各种功能。为了更容易地解释lncRNA的功能并对这些转录序列进行深入挖掘，将lncRNA分为不同的组是方便的。本文根据lncRNA的基因组定位和环境、对DNA序列的影响、作用机制和靶向机制等四个方面，对lncRNA的分类方法进行了综述。结合目前可用的功能注释，我们探索不同分类类别之间的潜在关系，并概括和比较每个类别中不同lncRNA的生物学特征。最后，我们提出了我们对潜在的进一步研究的看法。我们认为，上述lncRNA的分类对于lncRNA研究具有根本重要性，有助于进一步研究特定的lncRNA，基于lncRNA的不同特征提出新的假设，并探索潜在的lncRNA功能机制。
Long non-coding RNAs (lncRNAs) have been found to perform various functions in a wide variety of important biological processes. To make easier interpretation of lncRNA functionality and conduct deep mining on these transcribed sequences, it is convenient to classify lncRNAs into different groups. Here, we summarize classification methods of lncRNAs according to their four major features, namely, genomic location and context, effect exerted on DNA sequences, mechanism of functioning and their targeting mechanism. In combination with the presently available function annotations, we explore potential relationships between different classification categories, and generalize and compare biological features of different lncRNAs within each category. Finally, we present our view on potential further studies. We believe that the classifications of lncRNAs as indicated above are of fundamental importance for lncRNA studies, helpful for further investigation of specific lncRNAs, for formulation of new hypothesis based on different features of lncRNA and for exploration of the underlying lncRNA functional mechanisms.
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影响因子：
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通讯作者：
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