p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis.
p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis.
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p21 激活激酶 1 (PAK1) 表达与实体瘤预后相关：系统评价和荟萃分析
DOI：
10.18632/oncotarget.8320
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发表时间：
2016-05-10
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Fang F;Pan J;Li YP;Li G;Xu LX;Su GH;Li ZH;Feng X;Wang J
p21蛋白（Cdc 42/Rac）激活激酶1（PAK 1）的表达似乎是预测各种实体瘤的预后，尽管证据还没有定论。因此，我们进行了一项荟萃分析，以探讨PAK 1与实体瘤患者预后的关系。在几个广泛使用的数据库中检索了相关出版物，荟萃分析纳入了15项研究（3068例患者）。计算合并风险比（HR）和95%置信区间（CI），以评估PAK 1与预后之间的关联强度。PAK 1表达与总生存期（HR = 2.81，95%CI = 1.07-7.39）和疾病特异性生存期（HR = 2.15，95%CI = 1.47-3.16）的预后相关。但与肿瘤进展时间无相关性（HR = 1.78，95%CI = 0.99-3.21），提示PAK 1表达可能是实体瘤患者总生存期和疾病特异性生存期的预测指标。
p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) expression appears to be predictive of prognosis in various solid tumors, though the evidence is not yet conclusive. We therefore performed a meta-analysis to explore the relationship between PAK1 and prognosis in patients with solid tumors. Relevant publications were searched in several widely used databases, and 15 studies (3068 patients) were included in the meta-analysis. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between PAK1 and prognosis. Associations between PAK1 expression and prognosis were observed for overall survival (HR = 2.81, 95% CI = 1.07-7.39) and disease-specific survival (HR = 2.15, 95% CI = 1.47-3.16). No such association was detected for time to tumor progression (HR = 1.78, 95% CI = 0.99-3.21).Our meta-analysis thus indicates that PAK1 expression may be a predictive marker of overall survival and disease-specific survival in patients with solid tumors.
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