High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma.
High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma.
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KIF2A 高表达预示弥漫性大 B 细胞淋巴瘤的不良预后
DOI：
10.1007/s00277-017-3047-1
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发表时间：
2017-09
影响因子：
3.5
通讯作者：
Shi W
中科院分区：
文献类型：
--
作者：
Zhang Y;You X;Liu H;Xu M;Dang Q;Yang L;Huang J;Shi W
驱动蛋白家族成员2A（Kinesin family member 2A，KIF2A）是一种保守的运动蛋白，在多种恶性肿瘤的发病机制和预后中起着重要作用。本研究的目的是研究KIF2A在弥漫性大B细胞淋巴瘤（DLBCL）中的表达，评估KIF2A表达与疾病临床参数之间的相关性，并确定其预后价值。在134个DLBCL和57个反应性增生样本中使用组织芯片上的免疫组织化学评估KIF2A表达。单因素和多因素分析KIF2A表达与临床参数和预后的相关性。DLBCL组织样本中KIF2A的表达显著高于反应性增生受试者（P=0.002）。DLBCL中KIF 2A蛋白的表达与安阿伯分期（P=0.027）和国际预后指数（IPI）评分（P=0.01）有关。生存分析显示KIF2A表达（P=0.016）、血清LDH水平（P=0.049）和IPI评分（P<0.001）是DLBCL的独立预后指标。我们的研究结果还证实，下调KIF2A表达降低肿瘤细胞的活力，伴随着下调pAKT水平。总之，这些数据提供了第一个证据，即KIF2A表达增加预测DLBCL患者预后不良，以及通过靶向KIF2A治疗DLBCL的基本原理。
Kinesin family member 2A (KIF2A), a conserved motor protein, plays a critical role in the pathogenesis and prognosis of several malignant tumors. The aim of the present study was to investigate KIF2A expression in diffuse large B cell lymphoma (DLBCL), evaluate the association between KIF2A expression and the clinical parameters of the disease, and determine its prognostic value. KIF2A expression was evaluated in 134 DLBCL and 57 reactive hyperplasia samples using immunohistochemistry on a tissue microarray. The correlations between KIF2A expression with clinical parameters and prognosis were estimated using univariate and multivariate analyses. The expression of KIF2A was significantly higher in DLBCL tissue samples compared with those from subjects with reactive hyperplasia (P=0.002). Furthermore, increased expression of KIF2A protein in DLBCL was related to Ann Arbor stage (P=0.027) and international prognostic index (IPI) score (P=0.01). The survival analysis showed that KIF2A expression (P=0.016), serum LDH level (P=0.049), and IPI score (P<0.001) were independent prognostic markers for DLBCL. Our findings also confirmed that downregulating KIF2A expression decreased tumor cell viability, accompanied by downregulation of pAKT levels. Taken together, these data provide the first evidence that increased KIF2A expression predicts poor prognosis in patients with DLBCL, and a rationale for treatment of DLBCL by targeting KIF2A.
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影响因子：
3.8
作者：
Wang J;Ma S;Ma R;Qu X;Liu W;Lv C;Zhao S;Gong Y
通讯作者：
Gong Y
影响因子：
--
作者：
Haroon, Saroona;Hashmi, Atif Ali;Faridi, Naveen
通讯作者：
Faridi, Naveen
沉默 Kif2a 通过抑制 PI3K/Akt 信号通路诱导口腔舌鳞状细胞癌凋亡
影响因子：
3.4
作者：
Wang, Ketao;Lin, Changlong;Wei, Fengcai
通讯作者：
Wei, Fengcai
影响因子：
37.3
作者：
Vishwamitra D;Curry CV;Alkan S;Song YH;Gallick GE;Kaseb AO;Shi P;Amin HM
通讯作者：
Amin HM
影响因子：
11.2
作者：
Bian Y;Terse A;Du J;Hall B;Molinolo A;Zhang P;Chen W;Flanders KC;Gutkind JS;Wakefield LM;Kulkarni AB
通讯作者：
Kulkarni AB