Genetic variants in potassium channels are associated with type 2 diabetes in a Mongolian population.
Genetic variants in potassium channels are associated with type 2 diabetes in a Mongolian population.
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DOI：
10.1111/j.1753-0407.2011.00177.x
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发表时间：
2012-09
影响因子：
4.5
通讯作者：
Goldfarb LG
中科院分区：
文献类型：
--
作者：
Odgerel Z;Lee HS;Erdenebileg N;Gandbold S;Luvsanjamba M;Sambuughin N;Sonomtseren S;Sharavdorj P;Jodov E;Altaisaikhan K;Goldfarb LG
最近的全基因组关联研究（GWAS）已经确定了40多种与2型糖尿病（T2D）相关的常见序列变异。然而，在不同遗传背景的人群中，结果并不总是相同的。我们评估了一种假设，即生活在环境异常恶劣的地理区域的北亚人口产生了独特的遗传风险。根据GWAS在其他人群中进行的结果，我们对9个基因的21个单核苷酸多态性（snp）进行了基于人群的关联研究。研究参与者包括393名全血统蒙古人，177名诊断为T2D和216名匹配的对照组。采用TaqMan方法进行基因分型。在钾通道编码基因KCNQ1（最高OR=1.92； P=3.4×10−5）和ABCC8 （OR=1.79； P=5×10−4）基因中检测到最强的相关性。在其他人群（如KCNJ11或TCF7L2基因）中被确定为强烈影响T2D风险的遗传变异在蒙古没有显示出统计学上显著的相关性。蒙古人最强的T2D风险相关snp位于3个钾通道编码基因中的2个；这些基因的累积变异可能与极端寒冷的环境暴露有关。
Recent genome-wide association studies (GWAS) have identified more than 40 common sequence variants associated with type 2 diabetes (T2D). However, the results are not always the same in populations with differing genetic backgrounds. We evaluated a hypothesis that a North Asian population living in a geographic area with unusually harsh environmental conditions developed unique genetic risks. We performed a population-based association study with 21 single-nucleotide polymorphisms (SNPs) in 9 genes selected according to the results of GWAS conducted in other populations. The study participants included 393 full-heritage Mongolian individuals, 177 diagnosed with T2D and 216 matched controls. Genotyping was performed by TaqMan methodology. The strongest association was detected with SNPs located within the potassium-channel coding KCNQ1 (highest OR=1.92; P=3.4×10−5) and ABCC8 (OR=1.79; P=5×10−4) genes. Genetic variants identified as strongly influencing the risk of T2D in other populations such as those in KCNJ11 or TCF7L2 genes did not show statistically significant association in Mongolia. The strongest T2D risk-associated SNPs in Mongolians are located within 2 of 3 tested potassium-channel coding genes; accumulated variations in these genes may be related to environmental exposure to extreme cold.
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影响因子：
30.8
作者：
Zeggini, Eleftheria;Scott, Laura J.;Saxena, Richa;Voight, Benjamin F.;Marchini, Jonathan L.;Hu, Tianle;de Bakker, Paul I. W.;Abecasis, Goncalo R.;Almgren, Peter;Andersen, Gitte;Ardlie, Kristin;Bostroem, Kristina Bengtsson;Bergman, Richard N.;Bonnycastle, Lori L.;Borch-Johnsen, Knut;Burtt, Noel P.;Chen, Hong;Chines, Peter S.;Daly, Mark J.;Deodhar, Parimal;Ding, Chia-Jen;Doney, Alex S. F.;Duren, William L.;Elliott, Katherine S.;Erdos, Michael R.;Frayling, Timothy M.;Freathy, Rachel M.;Gianniny, Lauren;Grallert, Harald;Grarup, Niels;Groves, Christopher J.;Guiducci, Candace;Hansen, Torben;Herder, Christian;Hitman, Graham A.;Hughes, Thomas E.;Isomaa, Bo;Jackson, Anne U.;Jorgensen, Torben;Kong, Augustine;Kubalanza, Kari;Kuruvilla, Finny G.;Kuusisto, Johanna;Langenberg, Claudia;Lango, Hana;Lauritzen, Torsten;Li, Yun;Lindgren, Cecilia M.;Lyssenko, Valeriya;Marvelle, Amanda F.;Meisinger, Christa;Midthjell, Kristian;Mohlke, Karen L.;Morken, Mario A.;Morris, Andrew D.;Narisu, Narisu;Nilsson, Peter;Owen, Katharine R.;Palmer, Colin N. A.;Payne, Felicity;Perry, John R. B.;Pettersen, Elin;Platou, Carl;Prokopenko, Inga;Qi, Lu;Qin, Li;Rayner, Nigel W.;Rees, Matthew;Roix, Jeffrey J.;Sandbaek, Anelli;Shields, Beverley;Sjogren, Marketa;Steinthorsdottir, Valgerdur;Stringham, Heather M.;Swift, Amy J.;Thorleifsson, Gudmar;Thorsteinsdottir, Unnur;Timpson, Nicholas J.;Tuomi, Tiinamaija;Tuomilehto, Jaakko;Walker, Mark;Watanabe, Richard M.;Weedon, Michael N.;Willer, Cristen J.;Illig, Thomas;Hveem, Kristian;Hu, Frank B.;Laakso, Markku;Stefansson, Kari;Pedersen, Oluf;Wareham, Nicholas J.;Barroso, Ines;Hattersley, Andrew T.;Collins, Francis S.;Groop, Leif;McCarthy, Mark I.;Boehnke, Michael;Altshuler, David
通讯作者：
Altshuler, David
影响因子：
5.3
作者：
Munkhtulga, Lkhagvasuren;Nakayama, Kazuhiro;Iwamoto, Sadahiko
通讯作者：
Iwamoto, Sadahiko
影响因子：
7.7
作者：
Hamming KS;Soliman D;Matemisz LC;Niazi O;Lang Y;Gloyn AL;Light PE
通讯作者：
Light PE
影响因子：
7.7
作者：
Tarasov AI;Nicolson TJ;Riveline JP;Taneja TK;Baldwin SA;Baldwin JM;Charpentier G;Gautier JF;Froguel P;Vaxillaire M;Rutter GA
通讯作者：
Rutter GA
影响因子：
30.8
作者：
Neyroud, N;Tesson, F;Guicheney, P
通讯作者：
Guicheney, P