Maternal serum heme-oxygenase-1 (HO-1) concentrations in early pregnancy and subsequent risk of gestational diabetes mellitus.
Maternal serum heme-oxygenase-1 (HO-1) concentrations in early pregnancy and subsequent risk of gestational diabetes mellitus.
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DOI：
10.1371/journal.pone.0048060
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Williams MA
中科院分区：
文献类型：
--
作者：
Qiu C;Hevner K;Enquobahrie DA;Williams MA
血红素加氧酶-1 （HO-1）浓度在糖耐量受损和2型糖尿病（T2DM）中升高。然而，没有研究检验HO-1浓度与妊娠期糖尿病（GDM）之间的关系。在一项病例对照研究中，我们对孕妇（186例GDM病例和191例妊娠期间血糖维持在低血糖水平的妇女）进行了前瞻性队列研究，评估了在妊娠16周采集的样本中母体血清HO-1浓度与随后GDM风险的平均关系。采用ELISA法检测孕妇血清HO-1浓度。我们拟合了多变量逻辑回归模型，以获得优势比（ORs）和95%置信区间（ci）的估计。妊娠早期发生GDM的妇女血清HO-1浓度中位数低于未发生GDM的妇女（1.60对1.80 ng/mL， p值= 0.002）。在调整了母亲年龄、种族、T2DM家族史和孕前体重指数后，与浓度<1.23 ng/mL（最低四分位数）的女性相比，HO-1≥3.05 ng/mL（最高十分位数）的女性GDM风险降低了74% （95% CI; 0.09-0.77）。血清HO-1浓度与随后的GDM风险呈负相关。这些发现强调了氧化应激在GDM发病机制中的作用。进一步的研究需要证实血清HO-1在GDM诊断中的临床应用，特别是在妊娠早期。
Heme oxygenase-1 (HO-1) concentrations have been recently reported to be elevated in impaired glucose tolerance and type 2 diabetes mellitus (T2DM). However, no study has examined the association between HO-1 concentrations and gestational diabetes mellitus (GDM). In a case-control study, nested within a prospective cohort of pregnant women (186 GDM cases and 191 women who remained eu-glycemic through pregnancy), we assessed the association of maternal serum HO-1 concentrations, measured in samples collected at 16 weeks gestation, on average, with subsequent risk of GDM. Maternal serum HO-1 concentrations were determined using ELISA. We fitted multivariate logistic regression models to derive estimates of odds ratios (ORs) and 95% confidence intervals (CIs). Median serum HO-1 concentrations in early pregnancy were lower in women who subsequently developed GDM compared with those who did not (1.60 vs. 1.80 ng/mL, p-value = 0.002). After adjusting for maternal age, race, family history of T2DM and pre-pregnancy body mass index, women with HO-1≥3.05 ng/mL (highest decile) experienced a 74% reduction of GDM risk (95% CI; 0.09–0.77) compared with women whose concentrations were<1.23 ng/mL (lowest quartile). Serum HO-1 concentrations were inversely associated with subsequent GDM risk. These findings underscore the role of oxidative stress in the pathogenesis of GDM. Additional studies are warranted to confirm the clinical utility of serum HO-1 in diagnosis of GDM, particularly in the early pregnancy.
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影响因子：
8.2
作者：
Jonas, JC;Guiot, Y;Henquin, JC
通讯作者：
Henquin, JC
影响因子：
7.2
作者：
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DOI：
10.1073/pnas.0502407102
发表时间：
2005-05-17
影响因子：
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作者：
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影响因子：
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作者：
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