Blood reservoir function in patients with Fontan circulation and asplenia syndrome
Blood reservoir function in patients with Fontan circulation and asplenia syndrome
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Fontan循环无脾综合征患者的血库功能
DOI：
10.1017/s104795111900129x
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发表时间：
2019
影响因子：
1
通讯作者：
Senzaki Hideaki
中科院分区：
文献类型：
--
作者：
Fuse Michitaka;Sugamoto Kenji;Kuwata Seiko;Sekiya Rika;Kawada Kohei;Toki Miku;Kaneko Masahiro;Iwamoto Yoichi;Ishido Hirotaka;Masutani Satoshi;Kenmochi Manabu;Saiki Hirofumi;Senzaki Hideaki
Splanchnic circulation constitutes a major portion of the vasculature capacitance and plays an important role in maintaining blood perfusion. Because patients with asplenia syndrome lack this vascular bed as a blood reservoir, they may have a unique blood volume and distribution, which may be related to their vulnerability to the haemodynamic changes often observed in clinical practice. During cardiac catheterisation, the mean circulatory filling pressure was calculated with the Valsalva manoeuvre in 19 patients with Fontan circulation, including 5 patients with asplenia syndrome. We also measured the cardiac output index and circulatory blood volume by using a dye dilution technique. The blood volume and the mean circulatory filling pressure and the venous capacitance in patients with asplenia syndrome were similar to those in the remaining patients with Fontan circulation (85 ± 14 versus 77 ± 18 ml/kg, p = 0.43, 31 ± 8 versus 27 ± 5 mmHg, p = 0.19, 2.8 ± 0.6 versus 2.9 ± 0.9 ml/kg/mmHg, p = 0.86). Unexpectedly, our data indicated that patients with asplenia syndrome, who lack splanchnic capacitance circulation, have blood volume and venous capacitance comparable to those in patients with splanchnic circulation. These data suggest that (1) there is a blood reservoir other than the spleen even in patients with asplenia; (2) considering the large blood pool of the spleen, the presence of a symmetrical liver may represent the possible organ functioning as a blood reservoir in asplenia syndrome; and (3) if this is indeed the case, there may be a higher risk of hepatic congestion in patients with Fontan circulation with asplenia syndrome than in those without.
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DOI：
--
发表时间：
2001
期刊：
Annals of the Academy of Medicine, Singapore
影响因子：
--
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发表时间：
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影响因子：
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通讯作者：
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影响因子：
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DOI：
10.1016/j.jtcvs.2016.11.061
发表时间：
2017-04-01
影响因子：
6
作者：
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