Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.
Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.
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DOI：
10.1016/j.chemphyslip.2014.03.002
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发表时间：
2014-07
影响因子：
3.4
通讯作者：
Guo L
中科院分区：
文献类型：
--
作者：
Davies SS;Guo L
膜和脂蛋白的过氧化作用将“惰性”磷脂转化为过多的氧化修饰的磷脂（oxPL），其可以充当信号分子。在这篇综述中，我们将讨论四个主要类别的oxPL：轻度含氧磷脂，磷脂与氧化截断酰基链，磷脂与环化酰基链，和磷脂已被氧化N-修饰其头基的反应性脂质物种。对于每一类oxPL，我们将审查其形成的化学机制，它们在生物样品中形成的证据，与它们相关的生物活性和信号通路，以及它们消除的分解代谢途径。最后，我们将简要强调一些关键问题，仍然是关于oxPL在生理和疾病中的作用。
Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease.
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DOI：
10.1161/atvbaha.110.205666
发表时间：
2010-07
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Al-Shawaf E;Naylor J;Taylor H;Riches K;Milligan CJ;O'Regan D;Porter KE;Li J;Beech DJ
通讯作者：
Beech DJ
影响因子：
4.8
作者：
Ashraf, Mohammad Z.;Kar, Niladri S.;Podrez, Eugene A.
通讯作者：
Podrez, Eugene A.
影响因子：
4.8
作者：
Brame, CJ;Boutaud, O;Roberts, LJ
通讯作者：
Roberts, LJ
影响因子：
64.8
作者：
Bochkov, VN;Kadl, A;Leitinger, N
通讯作者：
Leitinger, N
影响因子：
10.8
作者：
Ahmed, Z;Babaei, S;Connelly, PW
通讯作者：
Connelly, PW