Phagocytosis, innate immunity, and host-pathogen specificity.
Phagocytosis, innate immunity, and host-pathogen specificity.
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吞噬作用，先天免疫和宿主 - 病原体特异性。
DOI：
10.1084/jem.20031256
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发表时间：
2004-01-05
影响因子：
15.3
通讯作者：
Golenbock, DT
中科院分区：
文献类型：
--
作者：
Henneke, P;Golenbock, DT
在哺乳动物中，吞噬作用对多种生物事件至关重要，包括组织重塑和死亡细胞的持续清除。此外，吞噬作用是触发宿主防御入侵病原体的早期和关键事件，这是本评论的重点。吞噬包括一系列事件，从细胞表面受体对颗粒的结合和识别开始，然后在颗粒周围形成富含肌动蛋白的膜延伸。膜延伸的融合导致吞噬小体的形成，这先于吞噬小体成熟为吞噬溶酶体。吞噬溶酶体内的病原体通过降低pH值、水解和自由基攻击被破坏。由于这一过程，病原体衍生的分子可以在细胞表面呈现（抗原呈递），从而诱导获得性免疫(1)。这些由先天免疫系统介导的早期事件对宿主的生存至关重要。在这里，我们讨论了许多物种共享的先天免疫系统分子如何识别大类微生物亚结构的新见解，以及物种间受体的多样性，这种多样性已经进化到适应不同物种特定的环境挑战。
In mammals, phagocytosis is essential for a variety of biological events, including tissue remodeling and the continuous clearance of dying cells. Furthermore, phagocytosis represents an early and crucial event in triggering host defenses against invading pathogens, which is the focus of this commentary. Phagocytosis comprises a series of events, starting with the binding and recognition of particles by cell surface receptors, followed by the formation of actin-rich membrane extensions around the particle. Fusion of the membrane extensions results in phagosome formation, which precedes phagosome maturation into a phagolysosome. Pathogens inside the phagolysosome are destroyed by lowered pH, hydrolysis, and radical attack. As a result of this process, pathogen-derived molecules can be presented at the cell surface (antigen presentation), allowing the induction of acquired immunity (1). These early events that are mediated by the innate immune system are critical for host survival. Here we discuss new insights into how broad classes of microbial substructures are recognized by molecules of the innate immune system that are shared by many species, and the interspecies receptor diversity that has evolved to match distinct species-specific environmental challenges.
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影响因子：
30.5
作者：
Arbibe, L;Mira, JP;Knaus, UG
通讯作者：
Knaus, UG
DOI：
10.1084/jem.20030204
发表时间：
2004-01-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Schmitter T;Agerer F;Peterson L;Munzner P;Hauck CR
通讯作者：
Hauck CR
影响因子：
4.4
作者：
Henneke, P;Takeuchi, O;Golenbock, DT
通讯作者：
Golenbock, DT
影响因子：
3.1
作者：
Lerm, M;Pop, M;Schmidt, G
通讯作者：
Schmidt, G
影响因子：
4.4
作者：
Massari, P;Henneke, P;Wetzler, LM
通讯作者：
Wetzler, LM