The association between parental bonding and obsessive compulsive disorder in offspring at high familial risk.
The association between parental bonding and obsessive compulsive disorder in offspring at high familial risk.
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父母关系与高家族风险后代强迫症之间的关联。
DOI：
10.1016/j.jad.2008.01.025
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发表时间：
2008
影响因子：
6.6
通讯作者：
Nestadt,Gerald
中科院分区：
文献类型：
--
作者：
Wilcox,HollyC;Grados,Marco;Samuels,Jack;Riddle,MarkA;Bienvenu3rd,OscarJ;Pinto,Anthony;Cullen,Bernadette;Wang,Ying;Shugart,YinY;Liang,Kung-Yee;Nestadt,Gerald
背景：本研究的目的是评估来自父母结合工具（PBI）的养育因素与终身DSM-IV强迫症诊断之间的关系。数据来自465个家庭的约1200名成年人，作为强迫症大型家庭和遗传研究的一部分。研究了父亲和母亲三种养育因素与子女强迫症状态的关系；根据父母强迫症状况和家庭强迫症负担（多重与偶发）对分析进行分层。结果通过主成分因子分析，得出三个影响因素：父本关爱、过度保护和控制。母亲过度保护与家族性强迫症后代（家族性病例）的强迫症相关，但仅在父母均未受强迫症影响的情况下，这表明环境和遗传风险是独立的，但是附加的（OR=5.9, 95% CI 1.2, 29.9, p=0.031）。在遗传风险不高的人群（散发性病例）中，父系关爱是保护因素（OR=0.2, 95% CI 0.0, 0.8, p=0.027）。在散发性家庭中，母亲过度保护也与后代强迫症有关（OR=2.9, 95% CI 1.3, 6.6, p=0.012）。当父母中至少有一方患有强迫症时，父母的过度保护和照顾与后代的强迫症无关，这一发现直接解决了母亲或父亲的强迫症对养育子女产生不利影响的假设。结论本研究提供了证据，证明父母的某些方面可能对后代的强迫症发展有影响。需要对有强迫症风险的儿童进行前瞻性研究，以探索因果关系的方向。
BACKGROUNDThe aim of the current study is to estimate the association between parenting factors derived from the Parental Bonding Instrument (PBI) and a lifetime DSM-IV diagnosis of OCD.METHODData were from approximately 1200 adults from 465 families assessed as part of a large family and genetic study of OCD. The association of three parenting factors, for fathers and mothers, with offspring OCD status were examined; analyses were stratified by parental OCD status and family loading for OCD (multiplex versus sporadic).RESULTSThree factors were derived by principal components factor analysis of the PBI (maternal and paternal care, overprotection and control). Maternal overprotection was associated with OCD in offspring with familial OCD (familial cases) but only if neither parent was affected with OCD, which suggests independent but additive environmental and genetic risk (OR=5.9, 95% CI 1.2, 29.9, p=0.031). Paternal care was a protective factor in those not at high genetic risk (sporadic cases) (OR=0.2, 95% CI 0.0, 0.8, p=0.027). Maternal overprotection was also associated with offspring OCD in sporadic families (OR=2.9, 95% CI 1.3, 6.6, p=0.012). The finding that parental overprotection and care were not associated with offspring OCD when at least one parent had OCD addressed directly the hypothesis of maternal or paternal OCD adversely impacting parenting.CONCLUSIONSThis study provides evidence that aspects of parenting may contribute to the development of OCD among offspring. Prospective studies of children at risk for OCD are needed to explore the direction of causality.
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影响因子：
1.9
作者：
Black, DW;Gaffney, G;Gabel, J
通讯作者：
Gabel, J
影响因子：
--
作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
强迫症、恐慌症合并广场恐惧症患者亲子关系回忆
影响因子：
6.7
作者：
Lyse Turgeon;Kieron O'Connor;André Marchand;M. Freeston
通讯作者：
M. Freeston
影响因子：
4.6
作者：
BLATT, SJ;WEIN, SJ;QUINLAN, DM
通讯作者：
QUINLAN, DM
DOI：
10.1176/ajp.152.1.76
发表时间：
1995
期刊：
The American journal of psychiatry
影响因子：
--
作者：
D. Pauls;J. Alsobrook;W. Goodman;S. Rasmussen;J. Leckman
通讯作者：
D. Pauls;J. Alsobrook;W. Goodman;S. Rasmussen;J. Leckman