Extending healthy ageing: nutrient sensitive pathway and centenarian population.
Extending healthy ageing: nutrient sensitive pathway and centenarian population.
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DOI：
10.1186/1742-4933-9-9
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发表时间：
2012-04-23
期刊：
影响因子：
--
通讯作者：
Scapagnini G
中科院分区：
文献类型：
--
作者：
Davinelli S;Willcox DC;Scapagnini G
衰老对任何生物体来说都是一个挑战，人类长寿是一种复杂的表型。随着预期寿命的延长，在老龄化期间保持长期健康、功能和福祉已成为一项基本目标。为了加深我们对衰老过程的理解，分析百岁老人的表型可能是有益的，百岁老人可能是成功衰老的最佳例子之一。健康老龄化涉及基因、环境和生活方式因素之间的相互作用，尤其是饮食。除了评估与超长寿命相关的特定基因-环境相互作用外，重要的是关注可改变的生活方式因素，如饮食和营养，以实现健康寿命的延长。此外，更好地了解人类寿命可能有助于设计延长人类最佳健康持续时间的战略。在这篇文章中，我们简要讨论了老龄化和长寿的相关主题，特别关注百岁老人的饮食模式和在寿命调节中起关键作用的营养感应途径。最后，我们还讨论了Nrf2系统在促衰老信号传导中的潜在作用，强调其植物致热激活。
Ageing is a challenge for any living organism and human longevity is a complex phenotype. With increasing life expectancy, maintaining long-term health, functionality and well-being during ageing has become an essential goal. To increase our understanding of how ageing works, it may be advantageous to analyze the phenotype of centenarians, perhaps one of the best examples of successful ageing. Healthy ageing involves the interaction between genes, the environment, and lifestyle factors, particularly diet. Besides evaluating specific gene-environment interactions in relation to exceptional longevity, it is important to focus attention on modifiable lifestyle factors such as diet and nutrition to achieve extension of health span. Furthermore, a better understanding of human longevity may assist in the design of strategies to extend the duration of optimal human health. In this article we briefly discuss relevant topics on ageing and longevity with particular focus on dietary patterns of centenarians and nutrient-sensing pathways that have a pivotal role in the regulation of life span. Finally, we also discuss the potential role of Nrf2 system in the pro-ageing signaling emphasizing its phytohormetic activation.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
64.8
作者：
Honjoh, Sakiko;Yamamoto, Takuya;Nishida, Eisuke
通讯作者：
Nishida, Eisuke
影响因子：
17.1
作者：
Cao, Kan;Graziotto, John J.;Collins, Francis S.
通讯作者：
Collins, Francis S.
影响因子：
5.1
作者：
Fraser, GE
通讯作者：
Fraser, GE
DOI：
10.18632/aging.100139
发表时间：
2010-04
期刊：
Aging
影响因子：
--
作者：
Blagosklonny MV
通讯作者：
Blagosklonny MV