Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis.
Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis.
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DOI：
10.18632/aging.100139
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Blagosklonny MV
中科院分区：
文献类型：
--
作者：
Blagosklonny MV
健康寿命正在迅速增加，人类的衰老似乎被推迟了。正如最近发表在《自然》杂志上的文章所言，这些发现令人费解，因此可以称之为“长寿之谜”。为了解释目前寿命的增加，我讨论了某些遗传变异，如高度活跃的mTOR(雷帕霉素的mTarget)，可能会以加速衰老为代价增加早期寿命。换句话说，健壮和快速衰老可能是联系在一起的，而缓慢衰老的个体在过去过早死亡。因此，直到最近，大多数快速老龄化的人都设法活到了老年。文明的进步(特别是60年前)使衰老缓慢的人能够活到老年，现在成为健康的百岁老人。我讨论了为什么缓慢衰老表现为延缓(健康)衰老，为什么恶化速度与衰老无关，也考虑了不同时代雷帕霉素的假设使用以及人类长寿的未来。
Healthy life span is rapidly increasing and human aging seems to be postponed. As recently exclaimed in Nature, these findings are so perplexing that they can be dubbed the 'longevity riddle'. To explain current increase in longevity, I discuss that certain genetic variants such as hyper-active mTOR (mTarget of Rapamycin) may increase survival early in life at the expense of accelerated aging. In other words, robustness and fast aging may be associated and slow-aging individuals died prematurely in the past. Therefore, until recently, mostly fast-aging individuals managed to survive into old age. The progress of civilization (especially 60 years ago) allowed slow-aging individuals to survive until old age, emerging as healthy centenarians now. I discuss why slow aging is manifested as postponed (healthy) aging, why the rate of deterioration is independent from aging and also entertain hypothetical use of rapamycin in different eras as well as the future of human longevity.
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影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
DOI：
10.18632/aging.100040
发表时间：
2009-04-20
期刊：
Aging
影响因子：
--
作者：
Blagosklonny MV;Hall MN
通讯作者：
Hall MN
影响因子：
5.3
作者：
Mueller, Marc A.;Beutner, Frank;Thiery, Joachim
通讯作者：
Thiery, Joachim
影响因子：
56.9
作者：
Wilmoth, JR;Deegan, LJ;Horiuchi, S
通讯作者：
Horiuchi, S
影响因子：
4.3
作者：
Blagosklonny, Mikhail V.
通讯作者：
Blagosklonny, Mikhail V.