Genetic polymorphisms for BDNF, COMT, and APOE do not affect gait or ankle motor control in chronic stroke: A preliminary cross-sectional study.
Genetic polymorphisms for BDNF, COMT, and APOE do not affect gait or ankle motor control in chronic stroke: A preliminary cross-sectional study.
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DOI：
10.1080/10749357.2020.1762060
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发表时间：
2021-01
影响因子：
2.2
通讯作者：
Madhavan S
中科院分区：
文献类型：
--
作者：
Aljuhni R;Cleland BT;Roth S;Madhavan S
中风后的运动功能障碍是长期残疾的主要原因。功能恢复的程度可能受基因多态性的影响。
确定脑源性神经营养因子（BDNF）、儿茶酚 - O - 甲基转移酶（COMT）和载脂蛋白E（APOE）的基因多态性对慢性中风患者的步行速度、步行对称性和踝关节运动控制的影响。
根据BDNF（存在[MET组]或不存在[VAL组]Met等位基因）、COMT（存在[MET组]或不存在[VAL组]Met等位基因）和APOE（存在[ε4 +组]或不存在[ε4 -组]ε4等位基因）的基因多态性对38名慢性中风参与者进行比较。用10米步行测试测量舒适和最大步行速度。用GAITRite电子垫测量步态时空对称性；计算步长、步时、摆动时间和站立时间的对称比。踝关节运动控制通过执行踝关节跟踪任务的准确性来测量。
在BDNF、COMT或APOE组之间，任何变量均未检测到显著差异（p≥0.11）。
在这些初步研究结果中，BDNF、COMT和APOE的基因多态性似乎不会影响慢性中风患者的步行速度、步行对称性或踝关节运动表现。
Motor deficits after stroke are a primary cause of long-term disability. The extent of functional recovery may be influenced by genetic polymorphisms. Determine the effect of genetic polymorphisms for brain-derived neurotrophic factor (BDNF), catechol-O-methyltransferase (COMT), and apolipoprotein E (APOE) on walking speed, walking symmetry, and ankle motor control in individuals with chronic stroke. 38 participants with chronic stroke were compared based upon genetic polymorphisms for BDNF (presence [MET group] or absence [VAL group] of a Met allele), COMT (presence [MET group] or absence [VAL group] of a Met allele), and APOE (presence [ε4+ group] of absence [ε4- group] of ε4 allele). Comfortable and maximal walking speed were measured with the 10-meter walk test. Gait spatiotemporal symmetry was measured with the GAITRite electronic mat; symmetry ratios were calculated for step length, step time, swing time, and stance time. Ankle motor control was measured as the accuracy of performing an ankle tracking task. No significant differences were detected (p≥0.11) between the BDNF, COMT, or APOE groups for any variables. In these preliminary findings, genetic polymorphisms for BDNF, COMT, and APOE do not appear to affect walking speed, walking symmetry, or ankle motor performance in chronic stroke.
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影响因子：
2
作者：
Helm EE;Tyrell CM;Pohlig RT;Brady LD;Reisman DS
通讯作者：
Reisman DS
DOI：
10.1097/npt.0000000000000180
发表时间：
2017-07
期刊：
Journal of neurologic physical therapy : JNPT
影响因子：
--
作者：
Stewart JC;Cramer SC
通讯作者：
Cramer SC
影响因子：
4.2
作者：
Liepert, Joachim;Heller, Andreas;Schoenfeld, Ariel
通讯作者：
Schoenfeld, Ariel
影响因子：
3.5
作者：
Flansbjer, UB;Holmbäck, AM;Lexell, J
通讯作者：
Lexell, J
影响因子：
3.4
作者：
Madhavan, Sangeetha;Rogers, Lynn M.;Stinear, James W.
通讯作者：
Stinear, James W.