In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial Spin-Labeling MRI
In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial Spin-Labeling MRI
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镰状细胞病儿童血液测量的体内 T1 可改善动脉自旋标记 MRI 的脑血流定量
DOI：
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发表时间：
2016
影响因子：
3.5
通讯作者：
A. J. Nederveen
中科院分区：
文献类型：
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作者：
L. Václavů;V. Land;D. Heijtel;M. V. Osch;M. Cnossen;C. B. Majoie;Adam Bush;John C. Wood;K. Fijnvandraat;H. Mutsaerts;A. J. Nederveen
背景和目的：镰状细胞病患儿血细胞比容低，CBF升高，后者可通过动脉自旋标记MR成像进行评估。定量CBF值通过使用血液的纵向弛豫时间（T1血液）的估计获得。由于T1血依赖于健康个体的红细胞压积，我们研究了用MR成像测量体内T1血与从红细胞压积计算T1血或假设文献推荐的成人固定值的重要性，假设测量的T1血最适合镰状细胞病儿童的CBF定量。材料和方法：对39例镰状细胞病患者的四种T1血估计方法进行了研究，并随后用于动脉自旋标记MR成像的CBF定量。首先，我们使用文献推荐的1650 ms（T1血液固定）;其次，根据患者测量的红细胞压积计算的T1血液（T1血液-红细胞压积）;第三，使用Look-MRI成像序列在体内测量的T1血液（T1血液测量）;最后，本研究在镰状细胞病儿童中测量的T1血液的平均值（T1血液-镰状细胞病）。以相位对比MR成像获得的定量血流测量值作为CBF的参考值。研究结果：T1血液测量值（1818 ± 107 ms）高于文献推荐值1650 ms，显著低于T1血液红细胞压积（2058 ± 123 ms，P <0.001），最有趣的是，与红细胞压积测量值无关。使用T1血测量或T1血镰状细胞病提供了动脉自旋标记和相位对比MR成像参考值之间CBF的最佳一致性。结论：这项工作提倡使用患者特异性测量的T1血或标准化值（1818 ms）在SCD儿童的动脉自旋标记中定量CBF。
BACKGROUND AND PURPOSE: Children with sickle cell disease have low hematocrit and elevated CBF, the latter of which can be assessed with arterial spin-labeling MR imaging. Quantitative CBF values are obtained by using an estimation of the longitudinal relaxation time of blood (T1blood). Because T1blood depends on hematocrit in healthy individuals, we investigated the importance of measuring T1blood in vivo with MR imaging versus calculating it from hematocrit or assuming an adult fixed value recommended by the literature, hypothesizing that measured T1blood would be the most suited for CBF quantification in children with sickle cell disease. MATERIALS AND METHODS: Four approaches for T1blood estimation were investigated in 39 patients with sickle cell disease and subsequently used in the CBF quantification from arterial spin-labeling MR imaging. First, we used 1650 ms as recommended by the literature (T1blood-fixed); second, T1blood calculated from hematocrit measured in patients (T1blood-hematocrit); third, T1blood measured in vivo with a Look-Locker MR imaging sequence (T1blood-measured); and finally, a mean value from T1blood measured in this study in children with sickle cell disease (T1blood–sickle cell disease). Quantitative flow measurements acquired with phase-contrast MR imaging served as reference values for CBF. RESULTS: T1blood-measured (1818 ± 107 ms) was higher than the literature recommended value of 1650 ms, was significantly lower than T1blood-hematocrit (2058 ± 123 ms, P < .001), and, most interesting, did not correlate with hematocrit measurements. Use of either T1blood-measured or T1blood–sickle cell disease provided the best agreement on CBF between arterial-spin labeling and phase-contrast MR imaging reference values. CONCLUSIONS: This work advocates the use of patient-specific measured T1blood or a standardized value (1818 ms) in the quantification of CBF from arterial spin-labeling in children with SCD.
影响因子：
19.7
作者：
Jain, Varsha;Duda, Jeffrey;Wang, Danny J. J.
通讯作者：
Wang, Danny J. J.
影响因子：
158.5
作者：
Adams, RJ;McKie, VC;Wiznitzer, M
通讯作者：
Wiznitzer, M
通过连续动脉自旋标记 (CASL) MRI 测量的脑血流量与镰状细胞性贫血 (SCA) 儿童的神经认知功能之间呈负相关。
影响因子：
20.3
作者：
Strouse,JohnJ;Cox,ChristianeS;Melhem,EliasR;Lu,Hanzhang;Kraut,MichaelA;Razumovsky,Alexander;Yohay,Kaleb;vanZijl,PeterC;Casella,JamesF
通讯作者：
Casella,JamesF