Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure.
Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure.
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DOI：
10.1016/j.fct.2015.09.017
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发表时间：
2015-12
影响因子：
4.3
通讯作者：
Doerge, Daniel R.
中科院分区：
文献类型：
--
作者：
Beland, Frederick A.;Olson, Greg R.;Mendoza, Maria C. B.;Marques, M. Matilde;Doerge, Daniel R.
丙烯酰胺是烘焙和油炸淀粉类食物、烘焙咖啡和香烟烟雾中的污染物。我们曾报道丙烯酰胺是B6 C3 F1小鼠和F344/N大鼠的多器官致癌物，并推测丙烯酰胺通过代谢为环氧缩水甘油酰胺而被激活为最终致癌物。我们现在已经研究了在饮用水中以0、0.0875、0.175、0.35和0.70 mM的浓度对相同的啮齿动物品系施用2年的甘氨酰胺的致癌作用。在雄性和雌性小鼠中，哈氏腺、肺、前胃和皮肤的肿瘤显著增加。雌性小鼠乳腺和卵巢肿瘤的发病率也有所增加。在雄性和雌性大鼠中，甲状腺和口腔肿瘤以及单核细胞白血病显著增加。雄性大鼠的附睾/睾丸和心脏肿瘤也有所增加，而雌性大鼠的乳腺、阴蒂腺和前胃肿瘤也有所增加。在给予丙烯酰胺的小鼠和大鼠中获得了类似的肿瘤谱。这些数据表明，在这些生物测定的条件下，丙烯酰胺被有效地代谢为缩水甘油酰胺，丙烯酰胺的致癌活性是由于其转化为缩水甘油酰胺。
Acrylamide is a contaminant in baked and fried starchy foods, roasted coffee, and cigarette smoke. Previously we reported that acrylamide is a multi-organ carcinogen in B6C3F1mice and F344/N rats, and hypothesized that acrylamide is activated to an ultimate carcinogen through metabolism to the epoxide glycidamide. We have now examined the carcinogenic effects of glycidamide administered at 0, 0.0875, 0.175, 0.35 and 0.70 mM in drinking water to the same strains of rodents for two years. In male and female mice, there were significant increases in tumors of the Harderian gland, lung, forestomach, and skin. Female mice also had an increased incidence of tumors of the mammary gland and ovary. In male and female rats, there were significant increases in thyroid gland and oral cavity neoplasms and mononuclear cell leukemia. Male rats also had increases in tumors of the epididymis/testes and heart, while female rats demonstrated increases in tumors of the mammary gland, clitoral gland, and forestomach. A similar spectrum of tumors was obtained in mice and rats administered acrylamide. These data indicate that, under the conditions of these bioassays, acrylamide is efficiently metabolized to glycidamide and that the carcinogenic activity of acrylamide is due to its conversion into glycidamide.
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影响因子：
1.9
作者：
BAILER, AJ;PORTIER, CJ
通讯作者：
PORTIER, CJ
影响因子：
4.1
作者：
da Costa, GG;Churchwell, MI;Doerge, DR
通讯作者：
Doerge, DR
影响因子：
3.8
作者：
BERGMARK, E;CALLEMAN, CJ;COSTA, LG
通讯作者：
COSTA, LG
影响因子：
4.1
作者：
Bergmark, E
通讯作者：
Bergmark, E
DOI：
10.1006/faat.1995.1112
发表时间：
1995-08-01
期刊：
FUNDAMENTAL AND APPLIED TOXICOLOGY
影响因子：
--
作者：
FRIEDMAN, MA;DULAK, LH;STEDHAM, MA
通讯作者：
STEDHAM, MA