Notch inhibitors as a new tool in the war on cancer: a pathway to watch.
Notch inhibitors as a new tool in the war on cancer: a pathway to watch.
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DOI：
10.2174/138920109787315060
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发表时间：
2009-02
影响因子：
2.8
通讯作者：
Purow B
中科院分区：
文献类型：
--
作者：
Purow B
Notch是世纪上半叶在果蝇中发现的一条重要的发育途径。几十年后，人们发现这一通路在人类干细胞维持、细胞命运决定和癌症中发挥着核心作用。Notch家族成员在越来越多的癌症中被发现为致癌基因。虽然在剖析这种信号通路的复杂工作方面取得了重大进展，但Notch抑制剂的选择非常有限。然而，Notch抑制剂的先驱已经在两种癌症类型的临床试验中。本综述将讨论目前最先进的，在管道中的代理商，和未来的Notch抑制剂的潜在策略。Notch抑制剂在临床上的成功开发作为一种新的抗癌策略具有很大的前景。
Notch was first recognized as an important developmental pathway in Drosophila in the first half of the 20th century. Many decades later, this pathway has been found to play central roles in humans in stem cell maintenance, cell fate decisions, and in cancer as well. Notch family members are being revealed as oncogenes in an ever-increasing number of cancers. Though significant progress has been made in dissecting the complex workings of this signaling pathway, there are very limited options available for Notch inhibitors. However, the pioneering class of Notch inhibitors is already in clinical trials for two cancer types. This review will address the current state-of-the-art, agents in the pipeline, and potential strategies for future Notch inhibitors. Successful development of Notch inhibitors in the clinic holds great promise as a new anti-cancer strategy.
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