The Influence of Epigenetic Modifications on Metabolic Changes in White Adipose Tissue and Liver and Their Potential Impact in Exercise.
The Influence of Epigenetic Modifications on Metabolic Changes in White Adipose Tissue and Liver and Their Potential Impact in Exercise.
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DOI：
10.3389/fphys.2021.686270
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发表时间：
2021
影响因子：
4
通讯作者：
Libonati JR
中科院分区：
文献类型：
--
作者：
Axsom JE;Schmidt HD;Matura LA;Libonati JR
背景：表观遗传标记响应多种环境刺激，是基因转录的重要介质。许多染色质修饰酶协调对环境刺激的表观遗传反应，越来越多的研究探讨代谢底物或辅助因子的变化如何改变表观遗传修饰。本文中，我们对白色脂肪组织（WAT）和肝脏中代谢相关表观遗传变化的现有证据进行了系统回顾，并就运动如何影响这些组织中代谢相关表观遗传标记提出了次要假设。主要结论：表观遗传改变有助于WAT脂肪分解、肝脏新生脂肪生成和肝脏糖异生相关的复杂转录反应。虽然这些代谢反应可能会随着急性和慢性运动而改变，但需要直接测试。
Background: Epigenetic marks are responsive to a wide variety of environmental stimuli and serve as important mediators for gene transcription. A number of chromatin modifying enzymes orchestrate epigenetic responses to environmental stimuli, with a growing body of research examining how changes in metabolic substrates or co-factors alter epigenetic modifications. Scope of Review: Here, we provide a systematic review of existing evidence of metabolism-related epigenetic changes in white adipose tissue (WAT) and the liver and generate secondary hypotheses on how exercise may impact metabolism-related epigenetic marks in these tissues. Major Conclusions: Epigenetic changes contribute to the complex transcriptional responses associated with WAT lipolysis, hepatic de novo lipogenesis, and hepatic gluconeogenesis. While these metabolic responses may hypothetically be altered with acute and chronic exercise, direct testing is needed.
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影响因子：
29
作者：
Goodpaster BH;Sparks LM
通讯作者：
Sparks LM
影响因子：
64.5
作者：
Benayoun BA;Pollina EA;Ucar D;Mahmoudi S;Karra K;Wong ED;Devarajan K;Daugherty AC;Kundaje AB;Mancini E;Hitz BC;Gupta R;Rando TA;Baker JC;Snyder MP;Cherry JM;Brunet A
通讯作者：
Brunet A
影响因子：
29
作者：
Barres, Romain;Yan, Jie;Zierath, Juleen R.
通讯作者：
Zierath, Juleen R.
DOI：
10.1126/science.1198125
发表时间：
2011-03-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Feng D;Liu T;Sun Z;Bugge A;Mullican SE;Alenghat T;Liu XS;Lazar MA
通讯作者：
Lazar MA
影响因子：
2.5
作者：
Knudsen, Jakob G.;Joensen, Ella;Pilegaard, Henriette
通讯作者：
Pilegaard, Henriette