Early Gastrointestinal Neuropathy Assessed by Wireless Motility Capsules in Adolescents with Type 1 Diabetes.
Early Gastrointestinal Neuropathy Assessed by Wireless Motility Capsules in Adolescents with Type 1 Diabetes.
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DOI：
10.3390/jcm12051925
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发表时间：
2023-02-28
影响因子：
3.9
通讯作者：
Krogh K
中科院分区：
文献类型：
--
作者：
Rasmussen VF;Thrysøe M;Karlsson P;Vestergaard ET;Kristensen K;Christensen AR;Nyengaard JR;Terkelsen AJ;Brock C;Krogh K
Background: To assess the prevalence of objective signs of gastrointestinal (GI) autonomic neuropathy (AN) in adolescents with type 1 diabetes (T1D). In addition, to investigate associations between objective GI findings and self-reported symptoms or other findings of AN. Methods: Fifty adolescents with T1D and 20 healthy adolescents were examined with a wireless motility capsule to assess the total and regional GI transit times and motility index. GI symptoms were evaluated with the GI Symptom Rating Scale questionnaire. AN was evaluated with cardiovascular and quantitative sudomotor axon reflex tests. Results: There was no difference in GI transit times in adolescents with T1D and healthy controls. Adolescents with T1D had a higher colonic motility index and peak pressure than the controls, and GI symptoms were associated with low gastric and colonic motility index (all p < 0.05). Abnormal gastric motility was associated with the duration of T1D, while a low colonic motility index was inversely associated with “time in target range” for blood glucose (all p < 0.01). No associations were found between signs of GI neuropathy and other measures of AN. Conclusions: Objective signs of GI neuropathy are common in adolescents with T1D and it seems to require early interventions in patients at high risk of developing GI neuropathy.
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影响因子：
3.5
作者：
Hasler WL;May KP;Wilson LA;Van Natta M;Parkman HP;Pasricha PJ;Koch KL;Abell TL;McCallum RW;Nguyen LA;Snape WJ;Sarosiek I;Clarke JO;Farrugia G;Calles-Escandon J;Grover M;Tonascia J;Lee LA;Miriel L;Hamilton FA;NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
通讯作者：
NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
影响因子：
3.9
作者：
Kornum DS;Terkelsen AJ;Bertoli D;Klinge MW;Høyer KL;Kufaishi HHA;Borghammer P;Drewes AM;Brock C;Krogh K
通讯作者：
Krogh K
DOI：
10.1097/mpg.0000000000003198
发表时间：
2021-09-01
影响因子：
2.9
作者：
Brinck, Christian Emil;Mark, Esben Bolvig;Krogh, Klaus
通讯作者：
Krogh, Klaus
DOI：
10.1001/archpedi.1992.02160180078021
发表时间：
1992-06-01
影响因子：
--
作者：
BURGHEN, GA;MURRELL, LR;BURSTEIN, S
通讯作者：
BURSTEIN, S
影响因子：
5.8
作者：
Perano, Shiree J.;Rayner, Chris K.;Couper, Jenny J.
通讯作者：
Couper, Jenny J.