Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis.
Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis.
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DOI：
10.1111/nmo.13196
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发表时间：
2018-03
影响因子：
3.5
通讯作者：
NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
中科院分区：
文献类型：
--
作者：
Hasler WL;May KP;Wilson LA;Van Natta M;Parkman HP;Pasricha PJ;Koch KL;Abell TL;McCallum RW;Nguyen LA;Snape WJ;Sarosiek I;Clarke JO;Farrugia G;Calles-Escandon J;Grover M;Tonascia J;Lee LA;Miriel L;Hamilton FA;NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Wireless motility capsule (WMC) findings are incompletely defined in suspected gastroparesis. We aimed to characterize regional WMC transit and contractility in relation to scintigraphy, etiology, and symptoms in patients undergoing gastric emptying testing. A total of 209 patients with gastroparesis symptoms at NIDDK Gastroparesis Consortium centers underwent gastric scintigraphy and WMCs on separate days to measure regional transit and contractility. Validated questionnaires quantified symptoms. Solid scintigraphy and liquid scintigraphy were delayed in 68.8% and 34.8% of patients; WMC gastric emptying times (GET) were delayed in 40.3% and showed 52.8% agreement with scintigraphy; 15.5% and 33.5% had delayed small bowel (SBTT) and colon transit (CTT) times. Transit was delayed in ≥2 regions in 23.3%. Rapid transit was rarely observed. Diabetics had slower GET but more rapid SBTT versus idiopathics (P ≤ .02). GET delays related to greater scintigraphic retention, slower SBTT, and fewer gastric contractions (P ≤ .04). Overall gastroparesis symptoms and nausea/vomiting, early satiety/fullness, bloating/distention, and upper abdominal pain subscores showed no relation to WMC transit. Upper and lower abdominal pain scores (P ≤ .03) were greater with increased colon contractions. Constipation correlated with slower CTT and higher colon contractions (P = .03). Diarrhea scores were higher with delayed SBTT and CTT (P ≤ .04). Wireless motility capsules define gastric emptying delays similar but not identical to scintigraphy that are more severe in diabetics and relate to reduced gastric contractility. Extragastric transit delays occur in >40% with suspected gastroparesis. Gastroparesis symptoms show little association with WMC profiles, although lower symptoms relate to small bowel or colon abnormalities.
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影响因子：
3.5
作者：
Barshop, K.;Staller, K.;Kuo, B.
通讯作者：
Kuo, B.
影响因子：
3.5
作者：
Kloetzer, L.;Chey, W. D.;Kuo, B.
通讯作者：
Kuo, B.
影响因子：
3.1
作者：
Kuo, Braden;Maneerattanaporn, Monthira;Hasler, William L.
通讯作者：
Hasler, William L.
影响因子：
29.4
作者：
Parkman HP;Yates K;Hasler WL;Nguyen L;Pasricha PJ;Snape WJ;Farrugia G;Koch KL;Abell TL;McCallum RW;Lee L;Unalp-Arida A;Tonascia J;Hamilton F;National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
通讯作者：
National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
影响因子：
3.2
作者：
Bharucha AE;Camilleri M;Forstrom LA;Zinsmeister AR
通讯作者：
Zinsmeister AR