Reconstruction of Regenerative Stem Cell Niche by Cell Aggregate Engineering.
Reconstruction of Regenerative Stem Cell Niche by Cell Aggregate Engineering.
复制标题
通过细胞聚集体工程重建再生干细胞生态位。
DOI:
10.1007/7651_2018_186
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发表时间:
2019
期刊:
影响因子:
--
通讯作者:
Jin Yan
中科院分区:
文献类型:
--
作者:
Sui Bing Dong;Zhu Bin;Hu Cheng Hu;Zhao Pan;Jin Yan
The niche plays critical roles in regulating functionality and determining regenerative outcomes of stem cells, for which establishment of favorable microenvironments is in demand in translational medicine. In recent years, the cell aggregate technology has shown immense potential to reconstruct a beneficial topical niche for stem cell-mediated regeneration, which has been recognized as a promising concept for high-density stem cell delivery with preservation of the self-produced, tissue-specific extracellular matrix microenvironments. Here, we describe the basic methodology of stem cell aggregate-based niche engineering and quality check indexes prior to application.
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