Inhibition of thyroid hormone transport in plasma of rats by polychlorinated biphenyls.

Inhibition of thyroid hormone transport in plasma of rats by polychlorinated biphenyls.
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多氯联苯对大鼠血浆中甲状腺激素转运的抑制作用。

DOI:
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发表时间:
1989
期刊:
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
影响因子:
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通讯作者:
A. Brouwer
A. Brouwer
中科院分区:
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文献类型:
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作者:
A. Brouwer

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在这项研究中,报告了啮齿动物暴露于TCDD后甲状腺激素降低的机制,(Potter等人,1983年),多氯联苯(Grassle和Biesmann 1982; Brouwer,1987年)和多溴联苯(Gupta等人,1983年),在大鼠中以3,4,3 ',4'-四氯联苯(TCB)作为模型化合物,在转运蛋白甲状腺素运载蛋白(TTR)水平进行了研究。此外,还在大鼠体内研究了多氯联苯的商业混合物Aroclor 1254对血浆甲状腺激素浓度的影响,以预测在环境接触多氯联苯后,野生动物物种是否会发生类似的变化。
In this study the mechanism of thyroid hormone reductions reported in rodents, following exposure to TCDD (Potter et al, 1983), PCBs (Grassle and Biesmann 1982; Brouwer 1987) and polybrominated biphenyls (Gupta et al 1983), was investigated in rats at the level of the transport protein, transthyretin (TTR), using 3,4,3’,4’-tetrachlorobiphenyl (TCB) as a model compound. Moreover, the effects of a commercial mixture of PCBs, Aroclor 1254, on plasma thyroid hormone concentrations was investigated in rats, in order to predict whether similar alterations would possibly occur in wildlife species, following environmental exposure to PCBs.
多氯联苯 (PCB)、二苯并二恶英和二苯并呋喃与人血浆前白蛋白结合的理论研究。
DOI: 10.1021/jm00162a006
发表时间: 1986
影响因子: 7.3
作者:
Pedersen,LG;Darden,TA;Oatley,SJ;McKinney,JD
通讯作者: McKinney,JD
给予 2,3,7,8-四氯二苯并-p-二恶英后,大鼠出现低甲状腺素血症和体温过低。
DOI: 10.1016/0041-008x(83)90123-0
发表时间: 1983
影响因子: 3.8
作者:
Potter,CL;Sipes,IG;Russell,DH
通讯作者: Russell,DH