Cortical preparatory activity: representation of movement or first cog in a dynamical machine?
Cortical preparatory activity: representation of movement or first cog in a dynamical machine?
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DOI：
10.1016/j.neuron.2010.09.015
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发表时间：
2010-11-04
期刊：
影响因子：
16.2
通讯作者：
Shenoy, Krishna V.
中科院分区：
文献类型：
--
作者：
Churchland, Mark M.;Cunningham, John P.;Kaufman, Matthew T.;Ryu, Stephen I.;Shenoy, Krishna V.
运动皮层在运动和运动准备期间都是活跃的。一个常见的假设是，准备活动构成了运动活动的亚阈值形式：在向右运动期间活跃的神经元在准备向右运动期间变得适度活跃。我们问是否实际上观察到这种活动模式。我们发现事实并非如此：在单个神经元的水平上，预备调谐与运动周期调谐的相关性很弱。然而，有些矛盾的是，预备调谐可以捕捉到一个抽象的“空间”，描述了人口水平的运动活动模式的首选方向。事实上，这种关系比传统的调谐模型更好地解释了预备反应。这些结果是预期的，如果准备活动提供了一个动力系统的初始状态，其演变产生运动活动。因此，我们的研究结果表明，准备活动可能并不代表特定的因素，而可能发挥更机械的作用。
The motor cortices are active during both movement and movement preparation. A common assumption is that preparatory activity constitutes a sub-threshold form of movement activity: a neuron active during rightwards movements becomes modestly active during preparation of a rightwards movement. We asked whether this pattern of activity is in fact observed. We found that it was not: at the level of a single neuron, preparatory tuning was weakly correlated with movement-period tuning. Yet somewhat paradoxically, preparatory tuning could be captured by a preferred direction in an abstract ‘space’ that described the population-level pattern of movement activity. In fact, this relationship accounted for preparatory responses better than did traditional tuning models. These results are expected if preparatory activity provides the initial state of a dynamical system whose evolution produces movement activity. Our results thus suggest that preparatory activity may not represent specific factors, and may instead play a more mechanistic role.
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