Prognostic Models for Patients With Gleason Score 9 Prostate Cancer: A Population-Based Study.
Prognostic Models for Patients With Gleason Score 9 Prostate Cancer: A Population-Based Study.
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格里森评分 9 分前列腺癌患者的预后模型：一项基于人群的研究
DOI：
10.3389/fonc.2021.633312
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发表时间：
2021
影响因子：
4.7
通讯作者：
Gong K
中科院分区：
文献类型：
--
作者：
Qiu J;Cai D;Wang Z;Zhou J;Gong Y;Cai L;Gong K
目的：Gleason评分（GS）系统是目前国际上应用最广泛的前列腺癌（PCa）组织学分级方法之一。GS可以通过添加初级Gleason模式（GP）和次级GP来获得。前列腺标本中GP 4和GP 5的不同比例均可导致GS 9。在本研究中，我们探讨了GP 5 + 4或GP 4 + 5是否与GS 9型PCa患者的不同预后相关。材料与方法：对2004年至2009年期间来自监测、流行病学和最终结果项目的10，124名诊断为GS 9 PCa的受试者进行了一项基于人群的回顾性研究。进行1：1倾向评分匹配（PSM）以平衡GP 4 + 5和5 + 4组之间的基线特征，并比较两组之间的差异。采用考克斯回归分析和Fine-Gray竞争风险回归模型筛选与全因死亡率（ACM）和癌症特异性死亡率（CAM）显著相关的协变量。结果：与GP 4 + 5相比，GP 5 + 4在PSM前后发生ACM和CSM的危险性更高。在最初的队列中，ACM有8个独立的预测因子，分别是诊断时的年龄、种族、AJCC NM分期、PSA水平、治疗、GP和婚姻状况，经考克斯分析证实; CSM有9个独立的预测因子，分别是诊断时的年龄、种族、AJCC TNM分期、PSA水平、治疗、GP和婚姻状况，经竞争风险模型证实。结论：与GP 4 + 5相比，GP 5 + 4与较差的总生存期和癌症特异性生存期相关。
Purpose: Gleason score (GS) system is one of the most widely used histological grading methods for prostate cancer (PCa) all over the world. GS can be obtained by adding the primary Gleason pattern (GP) and secondary GP. Different proportions of GP 4 and GP 5 in prostate specimens can both lead to GS 9. In this study, we explored whether GP 5 + 4 or GP 4 + 5 was associated with different prognoses among patients with GS 9 PCa. Materials and methods: A retrospective population-based study was conducted on 10,124 subjects diagnosed with GS 9 PCa between 2004 and 2009 from the Surveillance, Epidemiology, and End Results program. A 1:1 propensity-score matching (PSM) was performed to balance the baseline characteristics between the GP 4 + 5 and 5 + 4 groups and to compare the prognoses between the two groups. Cox regression analysis and Fine-Gray competing risk regression models were adopted to screen the covariates significantly associated with all-cause mortality (ACM) and cancer-specific mortality (CAM). Results: GP 5 + 4 was associated with higher risks of ACM and CSM before or after PSM than GP 4 + 5. In the original cohort, there were eight independent predictors for ACM, which were age at diagnosis, race, AJCC NM stage, PSA levels, treatments, GP, and marital status, confirmed by the Cox analysis; and nine independent predictors for CSM, which were age at diagnosis, race, AJCC TNM stage, PSA levels, treatments, GP, and marital status, confirmed by the competing-risk model. Conclusion: GP 5 + 4 was associated with a poorer overall survival and cancer-specific survival compared with GP 4 + 5.
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影响因子：
3.5
作者：
Rebbeck, Timothy R.
通讯作者：
Rebbeck, Timothy R.
DOI：
10.1016/j.juro.2017.07.009
发表时间：
2017-12
期刊：
The Journal of urology
影响因子：
--
作者：
Stroup SP;Moreira DM;Chen Z;Howard L;Berger JH;Terris MK;Aronson WJ;Cooperberg MR;Amling CL;Kane CJ;Freedland SJ
通讯作者：
Freedland SJ
影响因子：
4.5
作者：
Pierorazio PM;Walsh PC;Partin AW;Epstein JI
通讯作者：
Epstein JI
影响因子：
6.2
作者：
National Cancer Institute Surveillance, Epidemiology, and End Results Prostate-Specific Antigen Working Group;Adamo MP;Boten JA;Coyle LM;Cronin KA;Lam CJ;Negoita S;Penberthy L;Stevens JL;Ward KC
通讯作者：
Ward KC
影响因子：
2.9
作者：
Huang TB;Zhou GC;Dong CP;Wang LP;Luan Y;Ye JT;Gu X;Yao XD;Zheng JH;Ding XF
通讯作者：
Ding XF