Prostate Cancer Genetics: Variation by Race, Ethnicity, and Geography.
Prostate Cancer Genetics: Variation by Race, Ethnicity, and Geography.
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DOI：
10.1016/j.semradonc.2016.08.002
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发表时间：
2017-01
影响因子：
3.5
通讯作者：
Rebbeck, Timothy R.
中科院分区：
文献类型：
--
作者：
Rebbeck, Timothy R.
前列腺癌的发病率因种族、民族和地理位置的不同而有很大差异。这些差异可以通过筛查和治疗的差异，暴露于前列腺癌风险因素的差异以及前列腺癌发生的潜在生物学差异（包括某些群体发展生物侵袭性疾病的基因组倾向）来解释。很明显，获得筛查和治疗是前列腺癌发病率的关键影响因素，但即使在地理位置不同的人群中，获得类似的护理（例如，在低收入和中等收入国家，非洲裔男子的前列腺癌发病率较高，预后较差。到目前为止，可以通过环境暴露来解释的前列腺癌比例很小，并且对这些因素在不同种族，民族或地理人群中的影响知之甚少。相比之下，前列腺癌在所有主要癌症中具有最高的遗传性。许多遗传易感性标记已被确定从家庭为基础的研究，候选基因关联研究，和全基因组关联研究。一些前列腺癌基因座，包括在染色体8q24发现的风险基因座，在迄今为止研究的所有组中具有一致的影响。然而，许多易感基因座在种族、民族和地理上的复制仍然有限，需要在某些人群（特别是非洲裔男性）中进行额外的研究，以更好地了解前列腺癌的潜在遗传基础。
Prostate cancer rates vary substantially by race, ethnicity, and geography. These disparities can be explained by variation in access to screening and treatment, variation in exposure to prostate cancer risk factors, and variation in the underlying biology of prostate carcinogenesis (including genomic propensity of some groups to develop biologically aggressive disease). It is clear that access to screening and treatment are critical influencers of prostate cancer rates, yet even among geographically diverse populations with similar access to care (e.g., low and medium income countries), African descent men have higher prostate cancer rates and poorer prognosis. To date, the proportion of prostate cancer that can be explained by environmental exposures is small, and the impact of these factors across different racial, ethnic, or geographical populations is poorly understood. In contrast, prostate cancer has one of the highest heritabilities of all major cancers. Numerous genetic susceptibility markers have been identified from family-based studies, candidate gene association studies, and genome-wide association studies. Some prostate cancer loci, including the risk loci found at chromosome 8q24, have consistent effects in all groups studied to date. However, replication of many susceptibility loci across race, ethnicity, and geography remains limited, and additional studies in certain populations (particularly in men of African descent) are needed to better understand the underlying genetic basis of prostate cancer.
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DOI：
10.1158/1055-9965.epi-12-0495
发表时间：
2012-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
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影响因子：
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通讯作者：
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影响因子：
2.8
作者：
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通讯作者：
Carpten, John D.
DOI：
10.1073/pnas.0910668107
发表时间：
2010-05-25
影响因子：
11.1
作者：
Ahmadiyeh, Nasim;Pomerantz, Mark M.;Freedman, Matthew L.
通讯作者：
Freedman, Matthew L.
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影响因子：
23.4
作者：
Cheng HH;Pritchard CC;Boyd T;Nelson PS;Montgomery B
通讯作者：
Montgomery B