Electroacupuncture Pretreatment Ameliorates PTSD-Like Behaviors in Rats by Enhancing Hippocampal Neurogenesis via the Keap1/Nrf2 Antioxidant Signaling Pathway
Electroacupuncture Pretreatment Ameliorates PTSD-Like Behaviors in Rats by Enhancing Hippocampal Neurogenesis via the Keap1/Nrf2 Antioxidant Signaling Pathway
复制标题
电针预处理通过 Keap1/Nrf2 抗氧化信号通路增强海马神经发生改善大鼠 PTSD 样行为
DOI：
10.3389/fncel.2019.00275
复制
发表时间：
2019-06
影响因子：
5.3
通讯作者：
Peng Zheng wu
中科院分区：
文献类型：
--
作者：
Zhou Cui hong;Xue Fen;Xue Shan shan;Sang Han fei;Liu Ling;Wang Ying;Cai Min;Zhang Zhang Jin;Tan Qing rong;Wang Hua ning;Peng Zheng wu
电针（EA）预处理是对多种脑部疾病具有临床应用价值的一种疗法。然而，它是否以及通过何种确切的分子机制改善创伤后应激障碍（PTSD）仍不清楚。在本研究中，大鼠……（最后一个单词“rec”不完整，无法准确翻译其所在的完整句子）
Electroacupuncture (EA) pretreatment is a clinically useful therapy for several brain disorders. However, whether and via which exact molecular mechanisms it ameliorates post-traumatic stress disorder (PTSD) remains unclear. In the present study, rats received EA stimulation for seven consecutive days before exposure to enhanced single prolonged stress (ESPS). Anxiety-like and fear learning behaviors; hippocampal neurogenesis; the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (keap1), and heme oxygenase 1 (HO-1); and the activity of AMP-activated kinase (AMPK) were evaluated at 14 days after ESPS. EA pretreatment improved hippocampal neurogenesis and ameliorated anxiety-like behaviors in ESPS-treated rats. EA pretreatment also increased the expression of Nrf2 and HO-1 and the activity of AMPK. Furthermore, Nrf2 knockdown by a short hairpin RNA affected anxiety-like behaviors and expression of neuroprotective markers (BDNF, DCX) in a manner similar to ESPS alone and dampened the neuroprotective effects of EA pretreatment. In contrast, Keap1 knockdown increased the expression of HO-1, improved hippocampal neurogenesis, and alleviated PTSD-like behaviors. Altogether, our results suggest that EA pretreatment ameliorates ESPS-induced anxiety-like behaviors and prevents hippocampal neurogenesis disruption in a rat model of PTSD possibly through regulation of the keap1/Nrf2 antioxidant defense pathway.
登录
查看更多内容
DOI：
10.1523/jneurosci.4099-08.2008
发表时间：
2008-12-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Vargas MR;Johnson DA;Sirkis DW;Messing A;Johnson JA
通讯作者：
Johnson JA
影响因子：
25.8
作者：
Liu H;Petukhova MV;Sampson NA;Aguilar-Gaxiola S;Alonso J;Andrade LH;Bromet EJ;de Girolamo G;Haro JM;Hinkov H;Kawakami N;Koenen KC;Kovess-Masfety V;Lee S;Medina-Mora ME;Navarro-Mateu F;O'Neill S;Piazza M;Posada-Villa J;Scott KM;Shahly V;Stein DJ;Ten Have M;Torres Y;Gureje O;Zaslavsky AM;Kessler RC;World Health Organization World Mental Health Survey Collaborators
通讯作者：
World Health Organization World Mental Health Survey Collaborators
DOI：
10.1186/1757-1626-3-38
发表时间：
2010-01-28
期刊：
Cases journal
影响因子：
--
作者：
Tuli N
通讯作者：
Tuli N
DOI：
10.2307/j.ctt1trkhws.13
发表时间：
2019-10
期刊：
Encyclopedia of Personality and Individual Differences
影响因子：
--
作者：
U. Koch;K. Cratsley
通讯作者：
U. Koch;K. Cratsley
氧化应激和成人神经发生。
影响因子：
4.8
作者：
Yuan, Ti-Fei;Gu, Simeng;Arias-Carrion, Oscar
通讯作者：
Arias-Carrion, Oscar